ZFIN Gene: zbtb11

ZFIN ID: ZDB-GENE-030131-5055

ZFIN ID: ZDB-GENE-030131-5055

Gene Name:

zinc finger and BTB domain containing 11

Gene Symbol:

zbtb11 Nomenclature History

Previous Names:

man, marsanne (1), mne, si:dkey-98p3.1, si:dkeyp-116g9.2, wu:fc06h02, wu:fe36e08 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 6 Mapping Details/Browsers

Description:

Predicted to have metal ion binding activity and nucleic acid binding activity. Involved in neutrophil differentiation. Predicted to localize to nucleus. Is expressed in head; intermediate cell mass of mesoderm; and nervous system. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human ZBTB11 (zinc finger and BTB domain containing 11).

Genome Resources:

Alliance (1), Gene:555217 (1), Ensembl(GRCz11):ENSDARG00000017886 (2)

GENE EXPRESSION
All Expression Data:	Fig. 2 from Keightley et al., 2017
Wild-type Stages, Structures:	Segmentation:1-4 somites (10.33h-11.66h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
	head intermediate cell mass of mesoderm nervous system whole organism

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
gl11	Point Mutation	Unknown	Missense	ENU
gl12	Complex	Unknown	Unknown	CRISPR
sa2282	Point Mutation	Unknown	Splice Site	ENU
sa14905	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa17282	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-zbtb11	gl12	1
MO1-zbtb11	N/A	1

PHENOTYPE

Data:	3 figures from Keightley et al., 2017
Observed in:	central nervous system eye fourth ventricle head myeloid cell neutrophil cell maturation neutrophil pericardial region splanchnocranium thymus T cell

DISEASE ASSOCIATED WITH zbtb11 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Intellectual developmental disorder, autosomal recessive 69	618383

DISEASE ASSOCIATED WITH zbtb11 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	neutrophil differentiation (more)
Cellular Component	nucleus (more)
Molecular Function	metal ion binding (more)

GO Terms (all 5)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	zbtb11-202 (1)	4090	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	zbtb11-002 (1)	1425	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM zbtb11 No data available

MARKER RELATIONSHIPS

zbtb11 Contained in:	[BAC] DKEYP-116G9 (1)
zbtb11 Contains:	[SNP] rs3727977 (1), rs3727978 (1), rs3727979 (1)
zbtb11 Encodes:	[EST] fc06h02, fe36e08

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_212650 (1)	1431 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX571699 (1)	173467 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F1RAC1 (1)	1146 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 17)

ORTHOLOGY for zbtb11 ( Chr: 6 )

CITATIONS (23)

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