Gene
gpd2
- ID
- ZDB-GENE-030131-4869
- Name
- glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
- Symbol
- gpd2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable glycerol-3-phosphate dehydrogenase (quinone) activity. Predicted to be involved in glycerol-3-phosphate metabolic process and glycerol-3-phosphate shuttle. Predicted to be active in mitochondrion. Is expressed in several structures, including adaxial cell; ectoderm; musculature system; pectoral fin bud; and peripheral olfactory organ. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GPD2 (glycerol-3-phosphate dehydrogenase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb853 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la025358Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa7579 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa9425 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17515 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33826 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45245 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| type 2 diabetes mellitus | Alliance | {Type 2 diabetes mellitus, susceptibility to} | 125853 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
| Domain | IPR002048 | EF-hand domain |
| Domain | IPR006076 | FAD dependent oxidoreductase |
| Domain | IPR031656 | Alpha-glycerophosphate oxidase, C-terminal |
| Family | IPR000447 | FAD-dependent glycerol-3-phosphate dehydrogenase |
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Domain Details Per Protein
| Protein | Length | Alpha-glycerophosphate oxidase, C-terminal | Alpha-glycerophosphate oxidase, C-terminal domain superfamily | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | FAD-dependent glycerol-3-phosphate dehydrogenase | FAD dependent oxidoreductase | FAD/NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q0P3X1
|
536 | ||||||||
|
UniProtKB:F1Q555
|
726 | ||||||||
|
UniProtKB:A0A8M2BDB8
|
729 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-199N13 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-287B3 | ZFIN Curated Data | |
| Encodes | EST | cb853 | Thisse et al., 2001 | |
| Encodes | EST | fe02f02 | ||
| Encodes | EST | IMAGE:7147983 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:153729 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192462 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045348 (1) | 2140 nt | ||
| Genomic | GenBank:CR854986 | 156618 nt | ||
| Polypeptide | UniProtKB:A0A8M2BDB8 (1) | 729 aa |
- Zhang, J., Qian, L., Wang, C., Teng, M., Duan, M., Chen, X., Li, X., Wang, C. (2020) UPLC-TOF-MS/MS metabolomics analysis of zebrafish metabolism by spirotetramat. Environmental pollution (Barking, Essex : 1987). 266:115310
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Robinson, J.L., Hall, J.R., Charman, M., Ewart, K.V., and Driedzic, W.R. (2011) Molecular Analysis, Tissue Profiles, and Seasonal Patterns of Cytosolic and Mitochondrial GPDH in Freeze-Resistant Rainbow Smelt (Osmerus mordax). Physiological and biochemical zoology : PBZ. 84(4):363-376
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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