Gene

gpd2

ID
ZDB-GENE-030131-4869
Name
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
Symbol
gpd2 Nomenclature History
Previous Names
  • cb853 (1)
  • im:7147983
  • mGPDH (1)
  • wu:fe02f02
  • zgc:153729
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity and glycerol-3-phosphate dehydrogenase (quinone) activity. Predicted to be involved in glycerol-3-phosphate metabolic process. Predicted to localize to mitochondrion. Is expressed in several structures, including adaxial cell; ectoderm; musculature system; pectoral fin bud; and peripheral olfactory organ. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GPD2 (glycerol-3-phosphate dehydrogenase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from Thisse et al., 2001
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gpd2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
type 2 diabetes mellitus Alliance {Type 2 diabetes mellitus, susceptibility to} 125853
Associated With gpd2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR018247 EF-Hand 1, calcium-binding site
Domain IPR002048 EF-hand domain
Domain IPR006076 FAD dependent oxidoreductase
Domain IPR031656 Alpha-glycerophosphate oxidase, C-terminal
Family IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase
Homologous_superfamily IPR011992 EF-hand domain pair
Homologous_superfamily IPR036188 FAD/NAD(P)-binding domain superfamily
Homologous_superfamily IPR038299 Alpha-glycerophosphate oxidase, C-terminal domain superfamily
Domain Details Per Protein
Protein Length Alpha-glycerophosphate oxidase, C-terminal Alpha-glycerophosphate oxidase, C-terminal domain superfamily EF-Hand 1, calcium-binding site EF-hand domain EF-hand domain pair FAD-dependent glycerol-3-phosphate dehydrogenase FAD dependent oxidoreductase FAD/NAD(P)-binding domain superfamily
UniProtKB:Q0P3X1 536
UniProtKB:F1R2R0 536
UniProtKB:F1Q555 726
UniProtKB:A0A2R8Q776 536
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations