Gene

plekhg4

ID

ZDB-GENE-030131-4824

Name

pleckstrin homology domain containing, family G (with RhoGef domain) member 4

Symbol

plekhg4 Nomenclature History

Previous Names

id:ibd5125
wu:fd99e06

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have guanyl-nucleotide exchange factor activity. Is expressed in several structures, including brain; midbrain neural keel; presumptive diencephalon; segmental plate; and ventricular zone. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 4. Orthologous to human PLEKHG4 (pleckstrin homology and RhoGEF domain containing G4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7154857 (20 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With plekhg4 Human Ortholog

No data available

Associated With plekhg4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR001251	CRAL-TRIO lipid binding domain
Domain	IPR001849	Pleckstrin homology domain
Family	IPR052231	Rho GEF and signaling-related domain-containing protein
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036865	CRAL-TRIO lipid binding domain superfamily

Domain Details Per Protein

Protein	Length	CRAL-TRIO lipid binding domain	CRAL-TRIO lipid binding domain superfamily	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	PH-like domain superfamily	Pleckstrin homology domain	Rho GEF and signaling-related domain-containing protein
UniProtKB:A0A8M9PS08 InterPro	1110
UniProtKB:E7FEK1 InterPro	2630
UniProtKB:A0A8M9QHX1 InterPro	1625
UniProtKB:A0A8M3B495 InterPro	2619
UniProtKB:A0A8M9Q2K4 InterPro	1099
UniProtKB:A0A8M2BGC7 InterPro	837

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	plekhg4-201 (1) Ensembl	Ensembl	8,998 nt	Select Tool
mRNA	plekhg4-202 (1) Ensembl	Ensembl	8,626 nt	Select Tool ZFIN BLAST
mRNA	plekhg4-203 (1) Ensembl	Ensembl	8,704 nt	Select Tool ZFIN BLAST
mRNA	plekhg4-204 (1) Ensembl	Ensembl	8,587 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations