Gene
anpeplb
- ID
- ZDB-GENE-030131-4781
- Name
- alanyl (membrane) aminopeptidase-like b
- Symbol
- anpeplb Nomenclature History
- Previous Names
-
- anpepa (1)
- fd60b03
- si:ch211-200o3.4
- wu:fd60b03
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be located in membrane. Predicted to be active in cytoplasm; extracellular space; and plasma membrane. Orthologous to human ANPEP (alanyl aminopeptidase, membrane).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa12011 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12973 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23291 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa23292 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa43096 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 5 of 5
Show
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR014782 | Peptidase M1, membrane alanine aminopeptidase |
| Domain | IPR024571 | ERAP1-like C-terminal domain |
| Domain | IPR045357 | Aminopeptidase N-like , N-terminal domain |
| Family | IPR001930 | Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase |
| Family | IPR034016 | Aminopeptidase N-type |
1 - 5 of 8 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Aminopeptidase N-like , N-terminal domain | Aminopeptidase N-like , N-terminal domain superfamliy | Aminopeptidase N-type | ERAP1-like C-terminal domain | Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase | Peptidase M1 family aminopeptidases | Peptidase M1, membrane alanine aminopeptidase | Peptidase M4/M1, CTD superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1LWJ7 | InterPro | 946 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
anpepa-201
(1)
|
Ensembl | 3,456 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-200O3 | ZFIN Curated Data | |
| Encodes | EST | fd60b03 |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044861 (1) | 3456 nt | ||
| Genomic | GenBank:BX548052 (1) | 146410 nt | ||
| Polypeptide | UniProtKB:Q1LWJ7 (1) | 946 aa |
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Postlethwait, J.H., Farnsworth, D.R., Miller, A.C. (2020) An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. ZFIN Direct Data Submission.
1 - 2 of 2
Show