Gene
pfas
- ID
- ZDB-GENE-030131-4420
- Name
- phosphoribosylformylglycinamidine synthase
- Symbol
- pfas Nomenclature History
- Previous Names
-
- fd05a06
- si:dkey-183n20.16
- wu:fd05a06
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable phosphoribosylformylglycinamidine synthase activity. Predicted to be involved in purine nucleotide biosynthetic process. Predicted to act upstream of or within glutamine metabolic process. Predicted to be active in cytoplasm. Is expressed in brain; digestive system; eye; heart; and muscle. Orthologous to human PFAS (phosphoribosylformylglycinamidine synthase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Li et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR010918 | PurM-like, C-terminal domain |
| Domain | IPR040707 | Phosphoribosylformylglycinamidine synthase, N-terminal |
| Domain | IPR041609 | Phosphoribosylformylglycinamidine synthase, linker domain |
| Domain | IPR055181 | FGAR-AT, PurM N-terminal-like domain |
| Family | IPR010073 | Phosphoribosylformylglycinamidine synthase PurL |
| Homologous_superfamily | IPR029062 | Class I glutamine amidotransferase-like |
| Homologous_superfamily | IPR036604 | Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily |
| Homologous_superfamily | IPR036676 | PurM-like, C-terminal domain superfamily |
| Homologous_superfamily | IPR036921 | PurM-like, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Class I glutamine amidotransferase-like | FGAR-AT, PurM N-terminal-like domain | Phosphoribosylformylglycinamidine synthase, linker domain | Phosphoribosylformylglycinamidine synthase, N-terminal | Phosphoribosylformylglycinamidine synthase PurL | Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily | PurM-like, C-terminal domain | PurM-like, C-terminal domain superfamily | PurM-like, N-terminal domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5TZ72 | InterPro | 1314 |
Interactions and Pathways
No data available
Plasmids
No data available