Gene

pfas

ID

ZDB-GENE-030131-4420

Name

phosphoribosylformylglycinamidine synthase

Symbol

pfas Nomenclature History

Previous Names

fd05a06
si:dkey-183n20.16
wu:fd05a06

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to enable ATP binding activity; metal ion binding activity; and phosphoribosylformylglycinamidine synthase activity. Predicted to be involved in 'de novo' IMP biosynthetic process and glutamine metabolic process. Predicted to act upstream of or within purine nucleotide biosynthetic process. Is expressed in brain; digestive system; eye; heart; and muscle. Orthologous to human PFAS (phosphoribosylformylglycinamidine synthase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Li et al., 2015

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pfas Human Ortholog

No data available

Associated With pfas Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR010918	PurM-like, C-terminal domain
Domain	IPR040707	Phosphoribosylformylglycinamidine synthase, N-terminal
Domain	IPR041609	Phosphoribosylformylglycinamidine synthase, linker domain
Family	IPR010073	Phosphoribosylformylglycinamidine synthase PurL
Homologous_superfamily	IPR029062	Class I glutamine amidotransferase-like
Homologous_superfamily	IPR036604	Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily
Homologous_superfamily	IPR036676	PurM-like, C-terminal domain superfamily
Homologous_superfamily	IPR036921	PurM-like, N-terminal domain superfamily