Gene
khsrp
- ID
- ZDB-GENE-030131-4357
- Name
- KH-type splicing regulatory protein
- Symbol
- khsrp Nomenclature History
- Previous Names
-
- fc10e10
- fc94c12
- sb:eu1000
- sb:eu1001
- wu:fb25b12
- wu:fc10e10
- wu:fc94c12
- zgc:163038
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables mRNA 3'-UTR AU-rich region binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in cytoplasm and nucleus. Orthologous to human KHSRP (KH-type splicing regulatory protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Thisse et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la021320Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa6606 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19616 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39709 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zko1108a | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-khsrp | China Zebrafish Resource Center (CZRC) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004087 | K Homology domain |
| Domain | IPR004088 | K Homology domain, type 1 |
| Domain | IPR015096 | Far upstream element-binding protein, C-terminal |
| Domain | IPR047369 | Far upstream element-binding protein 2, second type I K homology domain |
| Domain | IPR047370 | Far upstream element-binding protein 2, third type I K homology domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Far upstream element-binding protein 2, first type I K homology domain | Far upstream element-binding protein 2, fourth type I K homology domain | Far upstream element-binding protein 2, second type I K homology domain | Far upstream element-binding protein 2, third type I K homology domain | Far upstream element-binding protein, C-terminal | K Homology domain | K Homology domain, type 1 | K Homology domain, type 1 superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A4QP88 | InterPro | 666 | ||||||||
| UniProtKB:A0A8M2B6Z8 | InterPro | 639 | ||||||||
| UniProtKB:A0A8M1ND02 | InterPro | 666 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-196H16 | ZFIN Curated Data | |
| Contains | SNP | rs3727559 | ||
| Contains | SNP | rs3727560 | ||
| Contains | SNP | rs3727561 | ||
| Contains | SNP | rs3727562 | ||
| Contains | SNP | rs3727563 | ||
| Contains | SNP | rs3727564 | ||
| Encodes | EST | eu1000 | Thisse et al., 2005 | |
| Encodes | EST | eu1001 | Thisse et al., 2005 | |
| Encodes | EST | fb25b12 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001089428 (1) | 3027 nt | ||
| Genomic | GenBank:AL929150 (2) | 210602 nt | ||
| Polypeptide | UniProtKB:A0A8M1ND02 (1) | 666 aa |
- Vejnar, C.E., Abdelmessih, M., Takacs, C., Yartseva, V., Oikonomou, P., Christiano, R., Stoeckius, M., Lau, S., Lee, M., Beaudoin, J.D., Musaev, D., Darwich-Codore, H., Walther, T., Tavazoie, S., Cifuentes, D., Giraldez, A. (2019) Genome wide analysis of 3'-UTR sequence elements and proteins regulating mRNA stability during maternal-to-zygotic transition in zebrafish. Genome research. 29(7):1100-1114
- Sun, J., Yan, L., Shen, W., Meng, A. (2018) Maternal Ybx1 safeguards zebrafish oocyte maturation and maternal-to-zygotic transition by repressing global translation. Development (Cambridge, England). 145(19):
- Zhou, S., Zhao, H., Thongda, W., Zhang, D., Su, B., Yu, D., Peatman, E., Li, C. (2016) Galectins in channel catfish, Ictalurus punctatus: Characterization and expression profiling in mucosal tissues. Fish & shellfish immunology. 49:324-35
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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