Gene
nkx2.9
- ID
- ZDB-GENE-030131-4340
- Name
- NK2 transcription factor related, locus 9 (Drosophila)
- Symbol
- nkx2.9 Nomenclature History
- Previous Names
-
- fc92g07
- wu:fc92g07
- wu:fk49f03
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within ventral spinal cord interneuron differentiation. Predicted to be active in nucleus. Is expressed in central nervous system; neural plate; and trunk. Orthologous to human NKX2-8 (NK2 homeobox 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Yang et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeobox NK-like transcription regulators | Homeodomain | Homeodomain, metazoa |
---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9P8T3 | InterPro | 224 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
nkx2.9-201
(1)
|
Ensembl | 1,166 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-34N18 | ZFIN Curated Data | |
Encodes | EST | fc92g07 | ||
Encodes | EST | fk49f03 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001099603 (1) | 1522 nt | ||
Genomic | GenBank:BX511145 (1) | 102544 nt | ||
Polypeptide | UniProtKB:A0A8M9P8T3 (1) | 224 aa |
- Chen, F., Köhler, M., Cucun, G., Takamiya, M., Kizil, C., Cosacak, M.I., Rastegar, S. (2023) sox1a:eGFP transgenic line and single-cell transcriptomics reveal the origin of zebrafish intraspinal serotonergic neurons. iScience. 26:107342107342
- Mukaigasa, K., Sakuma, C., Yaginuma, H. (2021) The developmental hourglass model is applicable to the spinal cord based on single-cell transcriptomes and non-conserved cis-regulatory elements. Development, growth & differentiation. 63(7):372-391
- Sedykh, I., Keller, A.N., Yoon, B., Roberson, L., Moskvin, O.V., Grinblat, Y. (2017) Zebrafish Rfx4 controls dorsal and ventral midline formation in the neural tube. Developmental Dynamics : an official publication of the American Association of Anatomists. 247(4):650-659
- Arnold, C.R., Lamont, R.E., Walker, J.T., Spice, P.J., Chan, C.K., Ho, C.Y., Childs, S.J. (2015) Comparative analysis of genes regulated by Dzip1/iguana and Hedgehog in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 244(2):211-23
- Al Oustah, A., Danesin, C., Khouri-Farah, N., Farreny, M.A., Escalas, N., Cochard, P., Glise, B., and Soula, C. (2014) Dynamics of Sonic hedgehog signaling in the ventral spinal cord are controlled by intrinsic changes in source cells requiring Sulfatase 1. Development (Cambridge, England). 141(6):1392-1403
- Büttner, A., Busch, W., Klüver, N., Giannis, A., and Scholz, S. (2012) Transcriptional responses of zebrafish embryos exposed to potential sonic hedgehog pathway interfering compounds deviate from expression profiles of cyclopamine. Reproductive toxicology (Elmsford, N.Y.). 33(2):254-263
- Huang, P., Xiong, F., Megason, S.G., and Schier, A.F. (2012) Attenuation of notch and hedgehog signaling is required for fate specification in the spinal cord. PLoS Genetics. 8(6):e1002762
- Bergeron, S.A., Tyurina, O.V., Miller, E., Bagas, A., and Karlstrom, R.O. (2011) Brother of cdo (umleitung) is cell-autonomously required for Hedgehog-mediated ventral CNS patterning in the zebrafish. Development (Cambridge, England). 138(1):75-85
- Yang, L., Rastegar, S., and Strähle, U. (2010) Regulatory interactions specifying Kolmer-Agduhr interneurons. Development (Cambridge, England). 137(16):2713-2722
- Zheng, D., Kille, P., Feeney, G.P., Cunningham, P., Handy, R.D., and Hogstrand, C. (2010) Dynamic transcriptomic profiles of zebrafish gills in response to zinc supplementation. BMC Genomics. 11:553
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