Gene
guf1
- ID
- ZDB-GENE-030131-4289
- Name
- GTP binding elongation factor GUF1
- Symbol
- guf1 Nomenclature History
- Previous Names
-
- fc88c11
- im:6906935
- wu:fc88c11 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable mitochondrial ribosome binding activity. Predicted to be involved in positive regulation of translation. Predicted to act upstream of or within translation. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 40. Orthologous to human GUF1 (GTP binding elongation factor GUF1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6906935 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 40 | Alliance | ?Developmental and epileptic encephalopathy 40 | 617065 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR031157 | Tr-type G domain, conserved site |
| Domain | IPR000640 | Elongation factor EFG, domain V-like |
| Domain | IPR000795 | Translational (tr)-type GTP-binding domain |
| Domain | IPR004161 | Translation elongation factor EFTu-like, domain 2 |
| Domain | IPR005225 | Small GTP-binding domain |
| Domain | IPR013842 | GTP-binding protein LepA, C-terminal |
| Domain | IPR035654 | Elongation factor 4, domain IV |
| Family | IPR006297 | Elongation factor 4 |
| Homologous_superfamily | IPR009000 | Translation protein, beta-barrel domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR035647 | EF-G domain III/V-like |
| Homologous_superfamily | IPR038363 | LepA, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | EF-G domain III/V-like | Elongation factor 4 | Elongation factor 4, domain IV | Elongation factor EFG, domain V-like | GTP-binding protein LepA, C-terminal | LepA, C-terminal domain superfamily | P-loop containing nucleoside triphosphate hydrolase | Small GTP-binding domain | Translational (tr)-type GTP-binding domain | Translation elongation factor EFTu-like, domain 2 | Translation protein, beta-barrel domain superfamily | Tr-type G domain, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QKS4
|
650 | ||||||||||||
|
UniProtKB:E7FFK6
|
672 |
Interactions and Pathways
No data available
Plasmids
No data available