Gene
ell
- ID
- ZDB-GENE-030131-3946
- Name
- elongation factor RNA polymerase II
- Symbol
- ell Nomenclature History
- Previous Names
-
- wu:fc60b11
- zgc:63836
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within vasculogenesis. Predicted to be located in nucleus. Predicted to be part of transcription elongation factor complex. Orthologous to human ELL (elongation factor for RNA polymerase II).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ell | Zebrafish Nomenclature Committee | |
| MO1-ell | N/A | Zhou et al., 2009 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR010844 | Occludin homology domain |
| Domain | IPR019464 | RNA polymerase II elongation factor ELL, N-terminal |
| Family | IPR031176 | ELL/occludin family |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
| Homologous_superfamily | IPR042065 | E3 ubiquitin-protein ligase ELL-like |
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Domain Details Per Protein
| Protein | Length | E3 ubiquitin-protein ligase ELL-like | ELL/occludin family | Occludin homology domain | RNA polymerase II elongation factor ELL, N-terminal | Winged helix DNA-binding domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:Q6PEG4
|
633 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-202N20 | ZFIN Curated Data | |
| Encodes | EST | fc60b11 | ||
| Encodes | cDNA | MGC:63836 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199707 (1) | 3883 nt | ||
| Genomic | GenBank:AL773593 (2) | 202726 nt | ||
| Polypeptide | UniProtKB:Q6PEG4 (1) | 633 aa |
- Song, Y., Fan, S., Zhang, D., Li, J., Li, Z., Li, Z., Xiao, W., Wang, J. (2023) Zebrafish maoc1 Attenuates Spring Viremia of Carp Virus Propagation by Promoting Autophagy-Lysosome-Dependent Degradation of Viral Phosphoprotein. Journal of virology. 97(2):e0133822
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ritter, D.I., Dong, Z., Guo, S., and Chuang, J.H. (2012) Transcriptional enhancers in protein-coding exons of vertebrate developmental genes. PLoS One. 7(5):e35202
- Zhou, J., Feng, X., Ban, B., Liu, J., Wang, Z., and Xiao, W. (2009) The elongation factor ELL (Eleven-Nineteen Lysine-Rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation. The Journal of biological chemistry. 284(28):19142-19152
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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