Gene
zfyve26
- ID
- ZDB-GENE-030131-3286
- Name
- zinc finger, FYVE domain containing 26
- Symbol
- zfyve26 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable phosphatidylinositol-3-phosphate binding activity. Acts upstream of or within axonogenesis and oocyte development. Predicted to be active in centrosome and midbody. Is expressed in fertilized egg; nervous system; oocyte; and somatic cell. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 15. Orthologous to human ZFYVE26 (zinc finger FYVE-type containing 26).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ge1 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| p96re | Allele with one point mutation | Donor Splice Site of Exon 35 | Cryptic Donor Splice Site, Frameshift, Premature Stop | ENU | |
| sa22339 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa28151 | Allele with one point mutation | Unknown | Unknown | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary spastic paraplegia 15 | Alliance | Spastic paraplegia 15, autosomal recessive | 270700 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | FYVE zinc finger | Zinc finger FYVE domain-containing protein 26 | Zinc finger, FYVE/PHD-type | Zinc finger, FYVE-related | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QNA3 | InterPro | 2554 | |||||
| UniProtKB:F6NK88 | InterPro | 2552 | |||||
| UniProtKB:A0A8M9QF82 | InterPro | 2555 | |||||
| UniProtKB:A0A067YRV0 | InterPro | 2269 | |||||
| UniProtKB:F1Q533 | InterPro | 2551 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
zfyve26-201
(1)
|
Ensembl | 8,847 nt | ||
| mRNA |
zfyve26-202
(1)
|
Ensembl | 7,798 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001305560 (1) | 8847 nt | ||
| Genomic | GenBank:BX470227 (1) | 177716 nt | ||
| Polypeptide | UniProtKB:A0A8M9QF82 (1) | 2555 aa |
- Garg, V., André, S., Heyer, L., Kracht, G., Ruhwedel, T., Scholz, P., Ischebeck, T., Werner, H.B., Dullin, C., Engelmann, J., Möbius, W., Göpfert, M.C., Dosch, R., Geurten, B.R.H. (2024) Axon demyelination and degeneration in a zebrafish spastizin model of hereditary spastic paraplegia. Open Biology. 14:240100240100
- Zhou, S., Zhao, H., Thongda, W., Zhang, D., Su, B., Yu, D., Peatman, E., Li, C. (2016) Galectins in channel catfish, Ictalurus punctatus: Characterization and expression profiling in mucosal tissues. Fish & shellfish immunology. 49:324-35
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kanagaraj, P., Gautier-Stein, A., Riedel, D., Schomburg, C., Cerdà, J., Vollack, N., Dosch, R. (2014) Souffle/Spastizin Controls Secretory Vesicle Maturation during Zebrafish Oogenesis. PLoS Genetics. 10:e1004449
- Novarino, G., Fenstermaker, A.G., Zaki, M.S., Hofree, M., Silhavy, J.L., Heiberg, A.D., Abdellateef, M., Rosti, B., Scott, E., Mansour, L., Masri, A., Kayserili, H., Al-Aama, J.Y., Abdel-Salam, G.M., Karminejad, A., Kara, M., Kara, B., Bozorgmehri, B., Ben-Omran, T., Mojahedi, F., Mahmoud, I.G., Bouslam, N., Bouhouche, A., Benomar, A., Hanein, S., Raymond, L., Forlani, S., Mascaro, M., Selim, L., Shehata, N., Al-Allawi, N., Bindu, P.S., Azam, M., Gunel, M., Caglayan, A., Bilguvar, K., Tolun, A., Issa, M.Y., Schroth, J., Spencer, E.G., Rosti, R.O., Akizu, N., Vaux, K.K., Johansen, A., Koh, A.A., Megahed, H., Durr, A., Brice, A., Stevanin, G., Gabriel, S.B., Ideker, T., and Gleeson, J.G. (2014) Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. Science (New York, N.Y.). 343(6170):506-511
- Martin, E., Yanicostas, C., Rastetter, A., Naini, S.M., Maouedj, A., Kabashi, E., Rivaud-Péchoux, S., Brice, A., Stevanin, G., and Soussi-Yanicostas, N. (2012) Spatacsin and spastizin act in the same pathway required for proper spinal motor neuron axon outgrowth in zebrafish. Neurobiology of disease. 48(3):299-308
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Dosch, R., Wagner, D.S., Mintzer, K.A., Runke, G., Wiemelt, A.P., and Mullins, M.C. (2004) Maternal Control of Vertebrate Development before the Midblastula Transition; Mutants from the Zebrafish I. Developmental Cell. 6(6):771-780
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