ZFIN ID: ZDB-GENE-030131-3127
Gene Name: chondroitin sulfate synthase 1
Gene Symbol: chsy1    Nomenclature History

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Previous Names: chys1, wu:fc27h05, wu:fc27h06, zgc:64191

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have acetylgalactosaminyltransferase activity. Involved in several processes, including animal organ morphogenesis; chondroitin sulfate proteoglycan biosynthetic process; and pectoral fin development. Predicted to localize to Golgi cisterna membrane and integral component of membrane. Is expressed in several structures, including cranium; forerunner cell group; inner ear; optic primordium; and pectoral fin bud. Human ortholog(s) of this gene implicated in temtamy preaxial brachydactyly syndrome. Orthologous to human CHSY1 (chondroitin sulfate synthase 1).
Genome Resources: Alliance (1),  Gene:324407 (1),  Ensembl(GRCz11):ENSDARG00000079027 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9893 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40837 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-chsy1 N/A 6
    MO2-chsy1 N/A 1
    MO3-chsy1 N/A 3
    DISEASE ASSOCIATED WITH chsy1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    temtamy preaxial brachydactyly syndrome Alliance Temtamy preaxial brachydactyly syndrome 605282
    DISEASE ASSOCIATED WITH chsy1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cartilage morphogenesis (more)
    Cellular Component Golgi apparatus (more)
    Molecular Function acetylgalactosaminyltransferase activity (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA chsy1-201 (1)    Ensembl 3921
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM chsy1 No data available
    MARKER RELATIONSHIPS
    chsy1 Contained in: [BAC] CH73-44P7 (1), DKEY-180K7 (1) (order this)
    chsy1 Encodes: [EST] fc27h05, fc27h06 (1)
    [cDNA] MGC:64191 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212678 (1) 3982 nt
    Genomic GenBank:CU457792 (1) 172744 nt
    Select Tool
    Polypeptide UniProtKB:Q6P296 (1) 801 aa
    Sequence Information (all 15)
    ORTHOLOGY for chsy1 ( Chr: 7 )
    CITATIONS (30)