Gene

c3b.2

ID

ZDB-GENE-030131-3063

Name

complement component c3b, tandem duplicate 2

Symbol

c3b.2 Nomenclature History

Previous Names

c3.8 (1)
si:ch211-140f21.1
wu:fc26b08

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in nervous system development. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular space. Is expressed in brain; gill; liver; pleuroperitoneal region; and post-vent region. Human ortholog(s) of this gene implicated in several diseases, including complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; sickle cell anemia; and silicosis. Orthologous to human C3 (complement C3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With c3b.2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
age related macular degeneration 9	Alliance	{Macular degeneration, age-related, 9}	611378
complement component 3 deficiency	Alliance	C3 deficiency	613779
		{Hemolytic uremic syndrome, atypical, susceptibility to, 5}	612925

Associated With c3b.2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR047565	Alpha-macroglobulin-like, thiol-ester bond-forming region
Domain	IPR000020	Anaphylatoxin/fibulin
Domain	IPR001134	Netrin domain
Domain	IPR001599	Alpha-2-macroglobulin
Domain	IPR002890	Macroglobulin domain
Domain	IPR009048	Alpha-macroglobulin, receptor-binding
Domain	IPR011625	Alpha-2-macroglobulin, bait region domain
Domain	IPR011626	Alpha-macroglobulin-like, TED domain
Domain	IPR018933	Netrin module, non-TIMP type
Domain	IPR040839	Macroglobulin domain MG4
Domain	IPR041425	Complement C3/4/5, macroglobulin domain MG1
Domain	IPR041555	Macroglobulin domain MG3
Domain	IPR048848	Complement component 3, CUB domain, second segment
Family	IPR050473	Alpha-2-macroglobulin/Complement system
Homologous_superfamily	IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Homologous_superfamily	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR014756	Immunoglobulin E-set
Homologous_superfamily	IPR018081	Anaphylatoxin, complement system
Homologous_superfamily	IPR036595	Alpha-macroglobulin, receptor-binding domain superfamily