Gene

rnaset2

ID

ZDB-GENE-030131-2513

Name

ribonuclease T2

Symbol

rnaset2 Nomenclature History

Previous Names

RNase Dre2 (1)
fc10c06
wu:fc10c06
zgc:113369

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable endoribonuclease activity. Acts upstream of or within rRNA catabolic process. Predicted to be located in endoplasmic reticulum lumen and lysosomal lumen. Predicted to be active in extracellular region. Is expressed in several structures, including blastomere; digestive system; gonad; immature eye; and yolk. Used to study RNASET2-deficient cystic leukoencephalopathy. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; RNASET2-deficient cystic leukoencephalopathy; colorectal cancer (multiple); lung cancer; and mismatch repair cancer syndrome. Orthologous to human RNASET2 (ribonuclease T2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7157101 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 11 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rnaset2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
RNASET2-deficient cystic leukoencephalopathy	Alliance	Leukoencephalopathy, cystic, without megalencephaly	612951

Associated With rnaset2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
RNASET2-deficient cystic leukoencephalopathy	rnaset2^sh532/sh532	standard conditions	Hamilton et al., 2020
RNASET2-deficient cystic leukoencephalopathy	rnaset2^sa138/sa138; zf148Tg; zf149Tg	standard conditions	Weber et al., 2020
RNASET2-deficient cystic leukoencephalopathy	rnaset2^sa138/sa138; zf149Tg	standard conditions	Weber et al., 2020

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR018188	Ribonuclease T2, His active site 1
Active_site	IPR033130	Ribonuclease T2, His active site 2
Family	IPR001568	Ribonuclease T2-like
Family	IPR033697	Ribonuclease T2, eukaryotic
Homologous_superfamily	IPR036430	Ribonuclease T2-like superfamily

Domain Details Per Protein

Protein	Length	Ribonuclease T2, eukaryotic	Ribonuclease T2, His active site 1	Ribonuclease T2, His active site 2	Ribonuclease T2-like	Ribonuclease T2-like superfamily
UniProtKB:B8XY56 InterPro	240
UniProtKB:A0A8M9PY62 InterPro	240

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rnaset2-201 (1) Ensembl	Ensembl	1,216 nt	Select Tool ZFIN BLAST
mRNA	rnaset2-202 (1) Ensembl	Ensembl	754 nt	Select Tool ZFIN BLAST
mRNA	rnaset2-204 (1) Ensembl	Ensembl	1,237 nt	Select Tool ZFIN BLAST
mRNA	rnaset2-205 (1) Ensembl	Ensembl	5,204 nt	Select Tool ZFIN BLAST
ncRNA	rnaset2-203 (1) Ensembl	Ensembl	1,672 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations