Gene
rnaset2
- ID
- ZDB-GENE-030131-2513
- Name
- ribonuclease T2
- Symbol
- rnaset2 Nomenclature History
- Previous Names
-
- RNase Dre2 (1)
- fc10c06
- wu:fc10c06
- zgc:113369
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable RNA endonuclease activity. Acts upstream of or within rRNA catabolic process. Predicted to be located in endoplasmic reticulum lumen and lysosomal lumen. Predicted to be active in extracellular region. Is expressed in several structures, including blastomere; digestive system; gonad; immature eye; and yolk. Used to study RNASET2-deficient cystic leukoencephalopathy. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; RNASET2-deficient cystic leukoencephalopathy; colorectal cancer (multiple); lung cancer; and mismatch repair cancer syndrome. Orthologous to human RNASET2 (ribonuclease T2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7157101 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-rnaset2 | (2) | |
| MO1-rnaset2 | N/A | Haud et al., 2011 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| RNASET2-deficient cystic leukoencephalopathy | Alliance | Leukoencephalopathy, cystic, without megalencephaly | 612951 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ribonuclease T2, eukaryotic | Ribonuclease T2, His active site 1 | Ribonuclease T2, His active site 2 | Ribonuclease T2-like | Ribonuclease T2-like superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:B8XY56 | InterPro | 240 | |||||
| UniProtKB:A0A8M9PY62 | InterPro | 240 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rnaset2-201
(1)
|
Ensembl | 1,216 nt | ||
| mRNA |
rnaset2-202
(1)
|
Ensembl | 754 nt | ||
| mRNA |
rnaset2-204
(1)
|
Ensembl | 1,237 nt | ||
| mRNA |
rnaset2-205
(1)
|
Ensembl | 5,204 nt | ||
| ncRNA |
rnaset2-203
(1)
|
Ensembl | 1,672 nt |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(elavl3:rnaset2,cryaa:CFP) |
|
| 1 | Hamilton et al., 2020 | |
| Tg(mpeg1.1:rnaset2,cryaa:CFP) |
|
| 1 | Hamilton et al., 2020 | |
| Tg(ubb:rnaset2,cryaa:CFP) |
|
| 1 | Hamilton et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-270C19 | ZFIN Curated Data | |
| Encodes | EST | fc10c06 | ||
| Encodes | EST | IMAGE:7157101 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:113369 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193015 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001030064 (1) | 1237 nt | ||
| Genomic | GenBank:BX255965 (2) | 148298 nt | ||
| Polypeptide | UniProtKB:A0A8M9PY62 (1) | 240 aa |
- Rutherford, H.A., Candeias, D., Duncan, C.J.A., Renshaw, S.A., Hamilton, N. (2024) Macrophage transplantation rescues RNASET2-deficient leukodystrophy by replacing deficient microglia in a zebrafish model. Proceedings of the National Academy of Sciences of the United States of America. 121:e2321496121e2321496121
- Hamilton, N., Rutherford, H.A., Petts, J.J., Isles, H.M., Weber, T., Henneke, M., Gärtner, J., Dunning, M.J., Renshaw, S.A. (2020) The failure of microglia to digest developmental apoptotic cells contributes to the pathology of RNASET2-deficient leukoencephalopathy. Glia. 68(7):1531-1545
- Weber, T., Schlotawa, L., Dosch, R., Hamilton, N., Kaiser, J., Schiller, S., Wenske, B., Gärtner, J., Henneke, M. (2020) Zebrafish disease model of human RNASET2 deficient cystic leukoencephalopathy displays abnormalities in early microglia. Biology Open. 9(5):
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Haud, N., Kara, F., Diekmann, S., Henneke, M., Willer, J.R., Hillwig, M.S., Gregg, R.G., Macintosh, G.C., Gärtner, J., Alia, A., and Hurlstone, A.F. (2011) rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA. Proceedings of the National Academy of Sciences of the United States of America. 108(3):1099-1103
- Hillwig, M.S., Rizhsky, L., Wang, Y., Umanskaya, A., Essner, J.J., and Macintosh, G.C. (2009) Zebrafish RNase T2 genes and the evolution of secretory ribonucleases in animals. BMC Evolutionary Biology. 9:170
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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