cfbl

ID

ZDB-GENE-030131-2319

Name

complement factor b, like

Symbol

cfbl Nomenclature History

Previous Names

fc04c04
wu:fc04c04
zgc:158446 (1)

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable serine-type endopeptidase activity. Acts upstream of or within response to bacterium. Predicted to be located in cell surface and extracellular region. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); glomerulonephritis (multiple); sickle cell anemia; and type 1 diabetes mellitus. Orthologous to human CFB (complement factor B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Meijer et al., 2005

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cfbl Human Ortholog

No data available

Associated With cfbl Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR018114	Serine proteases, trypsin family, histidine active site
Domain	IPR000436	Sushi/SCR/CCP domain
Domain	IPR001254	Serine proteases, trypsin domain
Domain	IPR002035	von Willebrand factor, type A
Family	IPR001314	Peptidase S1A, chymotrypsin family
Family	IPR011360	Complement B/C2
Homologous_superfamily	IPR009003	Peptidase S1, PA clan
Homologous_superfamily	IPR035976	Sushi/SCR/CCP superfamily
Homologous_superfamily	IPR036465	von Willebrand factor A-like domain superfamily
Homologous_superfamily	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold