Gene
pik3r5
- ID
- ZDB-GENE-030131-2308
- Name
- phosphoinositide-3-kinase, regulatory subunit 5
- Symbol
- pik3r5 Nomenclature History
- Previous Names
-
- fc03h05
- si:ch73-203d16.1
- wu:fc03h05 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in G protein-coupled receptor signaling pathway and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Predicted to be part of phosphatidylinositol 3-kinase complex. Human ortholog(s) of this gene implicated in ataxia with oculomotor apraxia type 3 and colon cancer. Orthologous to human PIK3R5 (phosphoinositide-3-kinase regulatory subunit 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ataxia with oculomotor apraxia type 3 | Alliance | Ataxia-oculomotor apraxia 3 | 615217 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR019522 | Phosphoinositide 3-kinase regulatory subunit 5/6 |
Domain Details Per Protein
| Protein | Additional Resources | Length | Phosphoinositide 3-kinase regulatory subunit 5/6 |
|---|---|---|---|
| UniProtKB:A0A8M3BAC9 | InterPro | 865 | |
| UniProtKB:A0A8M9Q7E2 | InterPro | 874 | |
| UniProtKB:A0A0R4IPI8 | InterPro | 865 | |
| UniProtKB:A0AB32TLL8 | InterPro | 872 | |
| UniProtKB:A0AB32TW45 | InterPro | 872 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pik3r5-201
(1)
|
Ensembl | 2,823 nt | ||
| mRNA |
pik3r5-202
(1)
|
Ensembl | 4,659 nt | ||
| mRNA |
pik3r5-203
(1)
|
Ensembl | 4,591 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-203D16 | ZFIN Curated Data | |
| Contained in | BAC | CH211-279I13 | ZFIN Curated Data | |
| Encodes | EST | fc03h05 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009302367 (1) | 4165 nt | ||
| Genomic | GenBank:AL928622 (1) | 230557 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q7E2 (1) | 874 aa |
- Kok, F.O., Shin, M., Ni, C., Gupta, A., Grosse, A.S., van Impel, A., Kirchmaier, B.C., Peterson-Maduro, J., Kourkoulis, G., Male, I., DeSantis, D.F., Sheppard-Tindell, S., Ebarasi, L., Betsholtz, C., Schulte-Merker, S., Wolfe, S.A., Lawson, N.D. (2015) Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish. Developmental Cell. 32(1):97-108
- Encinas, P., Garcia-Valtanen, P., Chinchilla, B., Gomez-Casado, E., Estepa, A., and Coll, J. (2013) Identification of Multipath Genes Differentially Expressed in Pathway-Targeted Microarrays in Zebrafish Infected and Surviving Spring Viremia Carp Virus (SVCV) Suggest Preventive Drug Candidates. PLoS One. 8(9):e73553
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