Gene

he1.2

ID

ZDB-GENE-030131-2100

Name

hatching enzyme 1, tandem dupliate 2

Symbol

he1.2 Nomenclature History

Previous Names

he1b (1)
Zh-1 (1)
ZHce1 (1)
fb96f07
si:ch211-246m6.8
wu:fb96f07
zebrafish HCE homologue 1 (1)

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Enables metalloendopeptidase activity and zinc ion binding activity. Involved in proteolysis. Acts upstream of or within hatching. Predicted to be located in extracellular region. Is expressed in hatching gland cell. Orthologous to human ASTL (astacin like metalloendopeptidase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Sano et al., 2008

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With he1.2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Oocyte/zygote/embryo maturation arrest 11	619643

Associated With he1.2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001506	Peptidase M12A
Domain	IPR006026	Peptidase, metallopeptidase
Domain	IPR034039	Hatching enzyme, peptidase domain
Homologous_superfamily	IPR024079	Metallopeptidase, catalytic domain superfamily