ZFIN is now using GRCz12tu for Genomic Data
Gene
clcn6
- ID
- ZDB-GENE-030131-2056
- Name
- Cl-/H+ antiporter 6
- Symbol
- clcn6 Nomenclature History
- Previous Names
-
- wu:fb95f01
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable voltage-gated chloride channel activity. Predicted to be involved in chloride transport. Predicted to act upstream of or within monoatomic ion transport and transmembrane transport. Predicted to be located in late endosome membrane. Predicted to be active in late endosome and lysosomal membrane. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in coronary artery disease and neuronal ceroid lipofuscinosis 15. Orthologous to human CLCN6 (Cl-/H+ antiporter 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wang et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neuronal ceroid lipofuscinosis 15 | Alliance | Ceroid lipofuscinosis, neuronal, 15 | 619173 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CBS domain | CBS domain superfamily | Chloride channel | Chloride channel ClC-6 | Chloride channel, core | Voltage-gated chloride channel/antiporter |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7F798 | InterPro | 863 | ||||||
| UniProtKB:A0AC58GC56 | InterPro | 730 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers