Gene
gas8
- ID
- ZDB-GENE-030131-1980
- Name
- growth arrest-specific 8
- Symbol
- gas8 Nomenclature History
- Previous Names
-
- wu:fb93e12
- zgc:66271
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable microtubule binding activity. Involved in cilium movement involved in otolith formation and otolith tethering. Acts upstream of or within muscle cell development and positive regulation of smoothened signaling pathway. Predicted to be located in ciliary basal body and cytoplasm. Predicted to be active in Golgi apparatus and microtubule. Is expressed in neural tube; otic placode; otic vesicle; and pronephric duct. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 33. Orthologous to human GAS8 (growth arrest specific 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66271 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary ciliary dyskinesia 33 | Alliance | Ciliary dyskinesia, primary, 33 | 616726 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Growth arrest-specific protein 8 | Growth arrest-specific protein 8 domain |
|---|---|---|---|
|
UniProtKB:F1QNW4
|
475 |
Interactions and Pathways
No data available
Plasmids
No data available