Gene
drc4
- ID
- ZDB-GENE-030131-1980
- Name
- dynein regulatory complex subunit 4
- Symbol
- drc4 Nomenclature History
- Previous Names
-
- gas8 (1)
- wu:fb93e12
- zgc:66271
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable microtubule binding activity and small GTPase binding activity. Involved in cilium movement involved in otolith formation and otolith tethering. Acts upstream of or within muscle cell development and positive regulation of smoothened signaling pathway. Predicted to be located in ciliary basal body and cytoplasm. Predicted to be active in Golgi apparatus and microtubule. Is expressed in neural tube; otic placode; otic vesicle; and pronephric duct. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 33. Orthologous to human GAS8 (growth arrest specific 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66271 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa17198 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-drc4 | Thomas et al., 2014 | |
| MO1-drc4 | N/A | (2) |
| MO2-drc4 | N/A | Colantonio et al., 2009 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary ciliary dyskinesia 33 | Alliance | Ciliary dyskinesia, primary, 33 | 616726 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Growth arrest-specific protein 8 | Growth arrest-specific protein 8 domain |
|---|---|---|---|---|
| UniProtKB:F1QNW4 | InterPro | 475 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-94D16 | ZFIN Curated Data | |
| Contained in | Fosmid | ZFOS-446E12 | ZFIN Curated Data | |
| Encodes | EST | fb93e12 | ||
| Encodes | cDNA | MGC:66271 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199634 (1) | 1639 nt | ||
| Genomic | GenBank:CU570687 (1) | 36595 nt | ||
| Polypeptide | UniProtKB:F1QNW4 (1) | 475 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | DRC4 | 16 | Amino acid sequence comparison (1) |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Jędrychowska, J., Vardanyan, V., Wieczor, M., Marciniak, A., Czub, J., Amini, R., Jain, R., Shen, H., Choi, H., Kuznicki, J., Korzh, V. (2024) Mutant analysis of Kcng4b reveals how the different functional states of the voltage-gated potassium channel regulate ear development. Developmental Biology. 513:50-62
- Thomas, H.R., Percival, S.M., Yoder, B.K., Parant, J.M. (2014) High-Throughput Genome Editing and Phenotyping Facilitated by High Resolution Melting Curve Analysis. PLoS One. 9:e114632
- Kasai, K., Nishiyama, N., and Yamauchi, K. (2013) Characterization of Oncorhynchus mykiss 5-hydroxyisourate hydrolase/transthyretin superfamily: evolutionary and functional analyses. Gene. 531(2):326-336
- Evron, T., Philipp, M., Lu, J., Meloni, A.R., Burkhalter, M., Chen, W., and Caron, M.G. (2011) Growth arrest Specific 8 (Gas8) and GPCR kinase 2 (GRK2) cooperate in the control of smoothened signaling. The Journal of biological chemistry. 286(31):27676-86
- Colantonio, J.R., Vermot, J., Wu, D., Langenbacher, A.D., Fraser, S., Chen, J.N., and Hill, K.L. (2009) The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear. Nature. 457(7226):205-209
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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