Gene
exosc8
- ID
- ZDB-GENE-030131-1736
- Name
- exosome component 8
- Symbol
- exosc8 Nomenclature History
- Previous Names
-
- Opa-interacting protein 2 (3' exoribonuclease family) (1)
- wu:fb79a10
- zgc:110381
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have AU-rich element binding activity. Involved in axonogenesis; cerebellar Purkinje cell layer structural organization; and myelination. Predicted to localize to cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia. Is expressed in alar plate midbrain region; immature eye; midbrain; and retina. Orthologous to human EXOSC8 (exosome component 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7157503 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pontocerebellar hypoplasia type 1C | Alliance | Pontocerebellar hypoplasia, type 1C | 616081 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001247 | Exoribonuclease, phosphorolytic domain 1 |
| Domain | IPR015847 | Exoribonuclease, phosphorolytic domain 2 |
| Family | IPR033196 | Exosome complex component Rrp43 |
| Family | IPR050590 | Exosome complex component Rrp42 subfamily |
| Homologous_superfamily | IPR020568 | Ribosomal protein uS5 domain 2-type superfamily |
| Homologous_superfamily | IPR027408 | PNPase/RNase PH domain superfamily |
| Homologous_superfamily | IPR036345 | Exoribonuclease, PH domain 2 superfamily |
Domain Details Per Protein
| Protein | Length | Exoribonuclease, PH domain 2 superfamily | Exoribonuclease, phosphorolytic domain 1 | Exoribonuclease, phosphorolytic domain 2 | Exosome complex component Rrp42 subfamily | Exosome complex component Rrp43 | PNPase/RNase PH domain superfamily | Ribosomal protein uS5 domain 2-type superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6DRN4
|
277 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
exosc8-201
(1)
|
Ensembl | 969 nt | ||
| ncRNA |
exosc8-002
(1)
|
Ensembl | 847 nt | ||
| ncRNA |
exosc8-003
(1)
|
Ensembl | 407 nt |
Interactions and Pathways
No data available
Plasmids
No data available