Gene
cabin1
- ID
- ZDB-GENE-030131-1735
- Name
- calcineurin binding protein 1
- Symbol
- cabin1 Nomenclature History
- Previous Names
-
- fb79a07
- sb:eu2483
- si:ch211-53f16.1
- wu:fb79a07
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to contribute to nucleosome binding activity. Predicted to act upstream of or within chromatin organization. Predicted to be active in nucleus. Is expressed in integument; nervous system; optic cup; and pharyngeal arch. Human ortholog(s) of this gene implicated in ovarian carcinoma. Orthologous to human CABIN1 (calcineurin binding protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu2483 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa7162 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18932 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa21396 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34512 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41305 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41306 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Calcineurin-binding protein cabin-1, MEF2-binding domain | Histone transcription regulator 3/CABIN1 | Tetratricopeptide-like helical domain superfamily | Tetratricopeptide repeat |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B2B9
|
2262 | ||||
|
UniProtKB:A0A8M3B598
|
2284 | ||||
|
UniProtKB:A0A8M9QEB0
|
2283 | ||||
|
UniProtKB:A0A8M2BEN8
|
2220 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cabin1-201
(1)
|
Ensembl | 6,603 nt | ||
| mRNA |
cabin1-202
(1)
|
Ensembl | 3,920 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-197O15 | ZFIN Curated Data | |
| Contained in | BAC | CH211-53F16 | ZFIN Curated Data | |
| Encodes | EST | eu2483 | Thisse et al., 2005 | |
| Encodes | EST | fb79a07 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001245969 (1) | 7785 nt | ||
| Genomic | GenBank:CU459194 (1) | 101559 nt | ||
| Polypeptide | UniProtKB:A0A8M3B598 (1) | 2284 aa |
- Comparative Orthology
- Alliance
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | CABIN1 | 22 | Amino acid sequence comparison (1) |
- Dunn, K., Vashisht, A., Hammond-Weinberger, D.R. (2022) Comparative in situ hybridization protocols in zebrafish. Biotechniques. 73(3):123-130
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Hammond, D.R., and Udvadia, A.J. (2010) Cabin1 expression suggests roles in neuronal development. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(9):2443-2451
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