Gene
alox12
- ID
- ZDB-GENE-030131-1452
- Name
- arachidonate 12-lipoxygenase
- Symbol
- alox12 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables arachidonate 12(S)-lipoxygenase activity and calcium ion binding activity. Predicted to be involved in arachidonate metabolic process; lipid oxidation; and lipoxygenase pathway. Predicted to act upstream of or within lipid metabolic process. Located in nucleus. Is expressed in several structures, including EVL; digestive system; epidermal cell; epidermis; and periderm. Orthologous to several human genes including ALOX12 (arachidonate 12-lipoxygenase, 12S type).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64120 (10 images)
- IMAGE:7138147 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| mk210 | Allele with one deletion | Unknown | Unknown | CRISPR |
1 - 1 of 1
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-alox12 | Katikaneni et al., 2020 | |
| MO1-alox12 | N/A | Haas et al., 2011 |
| MO2-alox12 | N/A | Haas et al., 2011 |
| MO3-alox12 | N/A | (2) |
1 - 4 of 4
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Lipoxigenase, C-terminal domain superfamily | Lipoxygenase | Lipoxygenase, conserved site | Lipoxygenase, C-terminal | Lipoxygenase, mammalian | Lipoxygenase, vertebrates, PLAT domain | PLAT/LH2 domain | PLAT/LH2 domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7T2A9
|
670 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
alox12-201
(1)
|
Ensembl | 3,595 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-6N21 | ZFIN Curated Data | |
| Encodes | EST | fb72a11 | ||
| Encodes | EST | IMAGE:7138147 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:64120 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199618 (1) | 3567 nt | ||
| Genomic | GenBank:BX005022 (1) | 217582 nt | ||
| Polypeptide | UniProtKB:Q7T2A9 (1) | 670 aa |
- Liu, Q., Song, T., Chen, B., Zhang, J., Li, W. (2023) Ferroptosis of brain microvascular endothelial cells contributes to hypoxia-induced blood-brain barrier injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e22874e22874
- Lv, P., Liu, F. (2023) Heme-deficient primitive red blood cells induce HSPC ferroptosis by altering iron homeostasis during zebrafish embryogenesis. Development (Cambridge, England). 150(20):
- Ma, Y., Hui, K.L., Gelashvili, Z., Niethammer, P. (2023) Oxoeicosanoid signaling mediates early antimicrobial defense in zebrafish. Cell Reports. 42:111974111974
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Kulkarni, A., Pineros, A.R., Walsh, M.A., Casimiro, I., Ibrahim, S., Hernandez-Perez, M., Orr, K.S., Glenn, L., Nadler, J.L., Morris, M.A., Tersey, S.A., Mirmira, R.G., Anderson, R.M. (2021) 12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes. JCI insight. 6(14):
- Hernandez-Perez, M., Kulkarni, A., Samala, N., Sorrell, C., El, K., Haider, I., Mukhtar Aleem, A., Holman, T.R., Rai, G., Tersey, S.A., Mirmira, R.G., Anderson, R.M. (2020) A 12-lipoxygenase-Gpr31 signaling axis is required for pancreatic organogenesis in the zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(11):14850-14862
- Katikaneni, A., Jelcic, M., Gerlach, G.F., Ma, Y., Overholtzer, M., Niethammer, P. (2020) Lipid peroxidation regulates long-range wound detection through 5-lipoxygenase in zebrafish. Nature cell biology. 22(9):1049-1055
- Nayak, S., Al Ashhab, A., Zilberg, D., Khozin-Goldberg, I. (2020) Dietary Supplementation with Omega-6 LC-PUFA-Rich Microalgae Regulates Mucosal Immune Response and Promotes Microbial Diversity in the Zebrafish Gut. Biology. 9(6):
- Loynes, C.A., Lee, J.A., Robertson, A.L., Steel, M.J., Ellett, F., Feng, Y., Levy, B.D., Whyte, M.K.B., Renshaw, S.A. (2018) PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo.. Science advances. 4:eaar8320
- Nayak, S., Khozin-Goldberg, I., Cohen, G., Zilberg, D. (2018) Dietary Supplementation With ω6 LC-PUFA-Rich Algae Modulates Zebrafish Immune Function and Improves Resistance to Streptococcal Infection. Frontiers in immunology. 9:1960
1 - 10 of 21
Show