alox12

ID

ZDB-GENE-030131-1452

Name

arachidonate 12-lipoxygenase

Symbol

alox12 Nomenclature History

Previous Names

ALOX1 (1)
LOX1 (1)
wu:fb72a11
zgc:64120

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Enables arachidonate 12(S)-lipoxygenase activity and calcium ion binding activity. Predicted to be involved in arachidonate metabolic process; lipid oxidation; and lipoxygenase pathway. Predicted to act upstream of or within lipid metabolic process. Located in nucleus. Is expressed in several structures, including EVL; digestive system; epidermal cell; epidermis; and periderm. Orthologous to several human genes including ALOX12 (arachidonate 12-lipoxygenase, 12S type).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:64120 (10 images)
IMAGE:7138147 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With alox12 Human Ortholog

No data available

Associated With alox12 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020834	Lipoxygenase, conserved site
Domain	IPR001024	PLAT/LH2 domain
Domain	IPR013819	Lipoxygenase, C-terminal
Domain	IPR042062	Lipoxygenase, vertebrates, PLAT domain
Family	IPR000907	Lipoxygenase
Family	IPR001885	Lipoxygenase, mammalian
Homologous_superfamily	IPR036226	Lipoxigenase, C-terminal domain superfamily
Homologous_superfamily	IPR036392	PLAT/LH2 domain superfamily