Gene
arfgef1
- ID
- ZDB-GENE-030131-108
- Name
- ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
- Symbol
- arfgef1 Nomenclature History
- Previous Names
-
- hm:zeh1651
- im:7138204
- wu:fj64h08
- zeh1651
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to have ARF guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction. Orthologous to human ARFGEF1 (ADP ribosylation factor guanine nucleotide exchange factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Developmental delay, impaired speech, and behavioral abnormalities, with or without seizures | 619964 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000904 | Sec7 domain |
| Domain | IPR015403 | Mon2/Sec7/BIG1-like, HDS |
| Domain | IPR032629 | Mon2/Sec7/BIG1-like, dimerisation and cyclophilin-binding domain |
| Domain | IPR032691 | Mon2/Sec7/BIG1-like, HUS domain |
| Domain | IPR046455 | Sec7/BIG1-like, C-terminal domain |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR023394 | Sec7, C-terminal domain superfamily |
| Homologous_superfamily | IPR035999 | Sec7 domain superfamily |
Domain Details Per Protein
| Protein | Length | Armadillo-like helical | Armadillo-type fold | Mon2/Sec7/BIG1-like, dimerisation and cyclophilin-binding domain | Mon2/Sec7/BIG1-like, HDS | Mon2/Sec7/BIG1-like, HUS domain | Sec7/BIG1-like, C-terminal domain | Sec7, C-terminal domain superfamily | Sec7 domain | Sec7 domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AZ36
|
1870 | |||||||||
|
UniProtKB:A0A8M3AP80
|
1846 | |||||||||
|
UniProtKB:E7FGL2
|
1849 | |||||||||
|
UniProtKB:A0A8M3B6N5
|
1852 | |||||||||
|
UniProtKB:A0A8M3ANJ3
|
1864 | |||||||||
|
UniProtKB:A0A2R8Q904
|
1867 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arfgef1-201
(1)
|
Ensembl | 7,122 nt | ||
| mRNA |
arfgef1-202
(1)
|
Ensembl | 807 nt | ||
| mRNA |
arfgef1-203
(1)
|
Ensembl | 5,604 nt |
Interactions and Pathways
No data available
Plasmids
No data available