Gene

foxn1

ID
ZDB-GENE-021008-1
Name
forkhead box N1
Symbol
foxn1 Nomenclature History
Previous Names
  • nude (1)
  • whnb (1)
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Exhibits transcription regulatory region sequence-specific DNA binding activity. Involved in thymus development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in T-cell immunodeficiency, congenital alopecia, and nail dystrophy; alopecia; nail disease; and primary immunodeficiency disease. Is expressed in pharyngeal arch; pharyngeal arch 3-7 skeleton; thymic epithelium; thymus; and thymus primordium. Orthologous to human FOXN1 (forkhead box N1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
37 figures from 31 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With foxn1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
T-cell immunodeficiency, congenital alopecia, and nail dystrophy Alliance T-cell immunodeficiency, congenital alopecia, and nail dystrophy 601705
T-cell lymphopenia, infantile, with or without nail dystrophy, autosomal dominant 618806
Associated With foxn1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR030456 Fork head domain conserved site 2
Domain IPR001766 Fork head domain
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Fork head domain Fork head domain conserved site 2 Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:B3DH11 565
UniProtKB:Q7ZTC0 565
UniProtKB:F1R9K2 565
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations