Gene

foxn1

ID

ZDB-GENE-021008-1

Name

forkhead box N1

Symbol

foxn1 Nomenclature History

Previous Names

nude (1)
whnb (1)

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Exhibits transcription regulatory region sequence-specific DNA binding activity. Involved in thymus development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in T-cell immunodeficiency, congenital alopecia, and nail dystrophy; alopecia; nail disease; and primary immunodeficiency disease. Is expressed in pharyngeal arch; pharyngeal arch 3-7 skeleton; thymic epithelium; thymus; and thymus primordium. Orthologous to human FOXN1 (forkhead box N1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

42 figures from 36 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With foxn1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
T-cell immunodeficiency, congenital alopecia, and nail dystrophy	Alliance	T-cell immunodeficiency, congenital alopecia, and nail dystrophy	601705
		T-cell lymphopenia, infantile, with or without nail dystrophy, autosomal dominant	618806

Associated With foxn1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR030456	Fork head domain conserved site 2
Domain	IPR001766	Fork head domain
Domain	IPR047401	Forkhead box protein N1, forkhead domain
Family	IPR049624	Forkhead box protein N1/4
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily