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ZIRC
ZFIN ID: ZDB-GENE-021008-1
Gene Name: forkhead box N1
Gene Symbol: foxn1    Nomenclature History

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Previous Names: nude (1), whnb (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Exhibits transcription regulatory region sequence-specific DNA binding activity. Involved in thymus development. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in T-cell immunodeficiency, congenital alopecia, and nail dystrophy; alopecia; nail disease; and primary immunodeficiency disease. Is expressed in pharyngeal arch; pharyngeal arch 3-7 skeleton; thymic epithelium; thymus; and thymus primordium. Orthologous to human FOXN1 (forkhead box N1).
Genome Resources: Alliance (1),  Gene:266748 (1),  Ensembl(GRCz11):ENSDARG00000011879 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa35901 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45541 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-foxn1
    2
    MO1-foxn1 N/A 1
    MO2-foxn1 N/A 1
    MO3-foxn1 N/A 2
    DISEASE ASSOCIATED WITH foxn1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    T-cell immunodeficiency, congenital alopecia, and nail dystrophy Alliance T-cell immunodeficiency, congenital alopecia, and nail dystrophy 601705
    DISEASE ASSOCIATED WITH foxn1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process thymus development (more)
    Cellular Component nucleus (more)
    Molecular Function transcription regulatory region sequence-specific DNA binding (more)
    GO Terms (all 7)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA foxn1-201 (1)    Ensembl 2718
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM foxn1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    TgBAC(foxn1:mCherry) foxn1 mCherry Danio rerio 1 5
    MARKER RELATIONSHIPS
    foxn1 Contained in: [BAC] DKEY-234F12 (1) (order this)
    foxn1 Encodes: [cDNA] MGC:193870 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212573 (1) 1911 bp
    Genomic GenBank:BX663513 (1) 249413 bp Blast at MegaBLAST
    Polypeptide UniProtKB:B3DH11 (1) 565 aa
    Sequence Clusters UniGene:30207 (1)
    Sequence Information (all 16)
    ORTHOLOGY for foxn1 ( Chr: 15 )
    CITATIONS (55)