Gene
abl2
- ID
- ZDB-GENE-020809-2
- Name
- c-abl oncogene 2, non-receptor tyrosine kinase
- Symbol
- abl2 Nomenclature History
- Previous Names
-
- cb272 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable protein tyrosine kinase activity. Predicted to be involved in regulation of apoptotic process. Predicted to act upstream of or within protein phosphorylation. Is expressed in adaxial cell; myotome; and somite. Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb272 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR015015 | F-actin binding |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR035837 | Tyrosine-protein kinase ABL, SH2 domain |
| Family | IPR050198 | Non-receptor tyrosine kinases involved in cell signaling |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | F-actin binding | Non-receptor tyrosine kinases involved in cell signaling | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily | Tyrosine-protein kinase ABL, SH2 domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BEX3
|
1134 | |||||||||||||
|
UniProtKB:A0A8M2BE86
|
1181 | |||||||||||||
|
UniProtKB:A0A8M6Z7N2
|
1125 | |||||||||||||
|
UniProtKB:B0UXN7
|
1135 | |||||||||||||
|
UniProtKB:A0A0R4IYB8
|
1182 |
Interactions and Pathways
No data available
Plasmids
No data available