Gene

tfe3b

ID
ZDB-GENE-010919-3
Name
transcription factor binding to IGHM enhancer 3b
Symbol
tfe3b Nomenclature History
Previous Names
  • si:dkey-13a21.9
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within humoral immune response; positive regulation of transcription, DNA-templated; and regulation of osteoclast differentiation. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; ionocyte; lens placode; polster; and sensory system. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human TFE3 (transcription factor binding to IGHM enhancer 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tfe3b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
renal cell carcinoma Alliance Renal cell carcinoma, papillary, 1 300854
Intellectual developmental disorder, X-linked, syndromic, with pigmentary mosaicism and coarse facies 301066
Associated With tfe3b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Domain IPR021802 MiT/TFE transcription factors, C-terminal
Domain IPR031867 MiT/TFE transcription factors, N-terminal
Family IPR024100 Transcription factor E3
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Helix-loop-helix DNA-binding domain superfamily MiT/TFE transcription factors, C-terminal MiT/TFE transcription factors, N-terminal Myc-type, basic helix-loop-helix (bHLH) domain Transcription factor E3
UniProtKB:Q7SZX8 451
UniProtKB:A0A2R8Q945 399
UniProtKB:A0A2R8RZ90 420
UniProtKB:A0A2R8Q378 463
UniProtKB:F1R1N1 451
UniProtKB:A0A2R8QFU5 459
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations