Community Action Needed: Please respond to the NIH RFI
Gene

ehmt2

ID
ZDB-GENE-010501-6
Name
euchromatic histone-lysine N-methyltransferase 2
Symbol
ehmt2 Nomenclature History
Previous Names
  • bat8 (1)
  • G9A (1)
  • wu:fb63b12
  • wu:fu47h08
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to enable histone-lysine N-methyltransferase activity; p53 binding activity; and zinc ion binding activity. Acts upstream of or within camera-type eye photoreceptor cell differentiation; exocrine pancreas development; and regulation of histone H3-K9 methylation. Predicted to be located in nucleus. Is expressed in brain; eye; and intestine. Human ortholog(s) of this gene implicated in idiopathic pulmonary fibrosis. Orthologous to human EHMT2 (euchromatic histone lysine methyltransferase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ehmt2 Human Ortholog
No data available
Associated With ehmt2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001214 SET domain
Domain IPR007728 Pre-SET domain
Domain IPR020683 Ankyrin repeat-containing domain
Family IPR038034 Histone-lysine N-methyltransferase EHMT2
Family IPR043550 Histone-lysine N-methyltransferase EHMT1/EHMT2
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat-containing domain Ankyrin repeat-containing domain superfamily Histone-lysine N-methyltransferase EHMT1/EHMT2 Histone-lysine N-methyltransferase EHMT2 Pre-SET domain SET domain
UniProtKB:A5XBP1 145
UniProtKB:A0A0G2KCN9 1167
UniProtKB:A8TT22 1173
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations