ZFIN Fish: pkd1a^zf1067/zf1067

ZFIN ID: ZDB-FISH-180912-15

ZFIN ID: ZDB-FISH-180912-15

Fish name:	pkd1a^{zf1067/zf1067}
Genotype:	pkd1a^{zf1067/zf1067}
Targeting Reagent:	none

HUMAN DISEASE MODELED by pkd1a^{zf1067/zf1067}

Human Disease	Conditions	Citations
autosomal dominant polycystic kidney disease	standard conditions	Zhu et al., 2017

GENE EXPRESSION
Gene expression in pkd1a^{zf1067/zf1067}

RNA expression No data available

Protein expression

Antibody	Structure	Conditions	Figures
Ab1-atp1a1	pronephric duct basolateral plasma membrane	standard conditions	Fig. 1, Fig. 2 from Zhu et al., 2017
Ab4-mtor	whole organism	standard conditions	Fig. 2 from Zhu et al., 2017
Ab6-mtor	whole organism	standard conditions	Fig. 2 from Zhu et al., 2017

Reporter gene expression No data available

PHENOTYPE
Phenotype in pkd1a^{zf1067/zf1067}

Phenotype	Conditions	Figures
heart edematous, abnormal	standard conditions	Fig. 1 from Zhu et al., 2017
pronephric duct cystic, abnormal	standard conditions	Fig. 1, Fig. 6 from Zhu et al., 2017
pronephric duct cystic, ameliorated	chemical treatment by environment: carbamazepine, chemical treatment by environment: sirolimus	Fig. 6 from Zhu et al., 2017
pronephric duct cystic, ameliorated	chemical treatment by environment: carbamazepine	Fig. 6 from Zhu et al., 2017
pronephric duct cystic, ameliorated	chemical treatment by environment: minoxidil	Fig. 6 from Zhu et al., 2017
pronephric duct cystic, ameliorated	chemical treatment by environment: sirolimus	Fig. 6 from Zhu et al., 2017
pronephric duct cystic, ameliorated	chemical treatment by environment: bafilomycin A1	Fig. 6 from Zhu et al., 2017
pronephric duct cystic, exacerbated	standard conditions	Fig. 1 from Zhu et al., 2017
pronephric duct has fewer parts of type pronephric duct autophagosome, abnormal	chemical treatment by environment: bafilomycin A1	Fig. 2 from Zhu et al., 2017
pronephric duct morphology, normal	standard conditions	Fig. 4 from Zhu et al., 2017
pronephric duct autophagy decreased occurrence, abnormal	chemical treatment by environment: bafilomycin A1	Fig. 2 from Zhu et al., 2017
pronephric duct regulation of autophagy process quality, abnormal	standard conditions	Fig. 2 from Zhu et al., 2017
pronephric tubule dilated, abnormal	standard conditions	Fig. 1 from Zhu et al., 2017
pronephros renal filtration decreased occurrence, abnormal	standard conditions	Fig. 1, Fig. 6 from Zhu et al., 2017
pronephros renal filtration occurrence, ameliorated	chemical treatment by environment: bafilomycin A1	Fig. 6 from Zhu et al., 2017
pronephros renal filtration occurrence, ameliorated	chemical treatment by environment: sirolimus	Fig. 6 from Zhu et al., 2017
pronephros renal filtration occurrence, ameliorated	chemical treatment by environment: minoxidil	Fig. 6 from Zhu et al., 2017
pronephros renal filtration occurrence, ameliorated	chemical treatment by environment: carbamazepine	Fig. 6 from Zhu et al., 2017
pronephros development decreased process quality, abnormal	standard conditions	Fig. 1, Fig. 4 from Zhu et al., 2017
TOR signaling increased occurrence, abnormal	standard conditions	Fig. 2 from Zhu et al., 2017
whole organism Ab6-mtor labeling increased amount, abnormal	standard conditions	Fig. 2 from Zhu et al., 2017

CITATIONS (1)