ZFIN ID: ZDB-FISH-150901-24314
Fish name: ext2to273b/to273b
Genotype: ext2to273b/to273b
Targeting Reagent: none
HUMAN DISEASE MODELED by ext2to273b/to273b
Human Disease Conditions Citations
hereditary multiple exostoses standard conditions Wiweger et al., 2014
GENE EXPRESSION
Gene expression in ext2to273b/to273b
RNA expression
Expressed Gene Structure Conditions Figures
bmp2a standard conditions Fig. 2 with image from Grandel et al., 2000
bmper standard conditions Fig. 5 with image from Clément et al., 2008
cnmd standard conditions Fig. 4 with image from Clément et al., 2008
col2a1a standard conditions Fig. 4 with image from Clément et al., 2008
col10a1a standard conditions Fig. 5 with image from Clément et al., 2008
dlx2a standard conditions Fig. 3 with image from Wiweger et al., 2012
Fig. 2 with image from Grandel et al., 2000
dlx2b standard conditions Fig. 3 with image from Wiweger et al., 2012
en1a standard conditions Fig. 4 with image from Grandel et al., 2000
fabp4a standard conditions Fig. 4 with image from Wiweger et al., 2014
fgf4 standard conditions Fig. 2 with image from Grandel et al., 2000
fgf8a standard conditions Fig. 7 from Lee et al., 2004
Fig. 2 with image from Grandel et al., 2000
gdf5 standard conditions Fig. 4 with image from Clément et al., 2008
gja1b standard conditions Fig. 3 with image from Wiweger et al., 2012
hoxa9b standard conditions Fig. 6 with image from Grandel et al., 2000
hoxa10b standard conditions Fig. 6 with image from Grandel et al., 2000
hoxa11b standard conditions Fig. 6 with image from Grandel et al., 2000
hoxa13b standard conditions Fig. 6 with image from Grandel et al., 2000
hoxd10a standard conditions Fig. 5 with image from Grandel et al., 2000
hoxd11a standard conditions Fig. 5 with image from Grandel et al., 2000
hoxd12a standard conditions Fig. 5 with image from Grandel et al., 2000
hoxd13a standard conditions Fig. 5 with image from Grandel et al., 2000
isl1a standard conditions Fig. 7 from Lee et al., 2004
pitx2 standard conditions Fig. S3 with image from Wiweger et al., 2012
ptch2 standard conditions Fig. 7 from Lee et al., 2004
Fig. 3 with image from Grandel et al., 2000
reln standard conditions Fig. 4 with image from Di Donato et al., 2018
shha standard conditions Fig. 3 with image from Grandel et al., 2000
sox9a standard conditions Fig. 4 with imageFig. 6 with image from Clément et al., 2008
sp7 standard conditions Fig. 2 with imageFig. 3 with image from Wiweger et al., 2012
Fig. 5 with image from Clément et al., 2008
Reporter gene expression No data available
PHENOTYPE
Phenotype in ext2to273b/to273b
Phenotype Conditions Figures
adductor hyohyoid increased width, abnormal standard conditions Fig. 3 with image from Wiweger et al., 2014
adductor hyohyoid shortened, abnormal standard conditions Fig. 3 with image from Wiweger et al., 2014
adductor mandibulae increased width, abnormal standard conditions Fig. 3 with image from Wiweger et al., 2014
adductor mandibulae shortened, abnormal standard conditions Fig. 3 with image from Wiweger et al., 2014
adductor operculi increased width, abnormal standard conditions Fig. 3 with image from Wiweger et al., 2014
adductor operculi shortened, abnormal standard conditions Fig. 3 with image from Wiweger et al., 2014
adipose tissue development premature, abnormal standard conditions Fig. 4 with image from Wiweger et al., 2014
apical ectodermal ridge pectoral fin bud aplastic, abnormal standard conditions Fig. 1 with image from Grandel et al., 2000
cartilage development disrupted, abnormal standard conditions Fig. 1 with imageFig. 6 with image from Clément et al., 2008
cartilage element decreased length, abnormal standard conditions Fig. 1 with image from Clément et al., 2008
cartilage element increased thickness, abnormal standard conditions Fig. 1 with image from Clément et al., 2008
cell junction organization process quality, normal standard conditions Fig. 5 from Wiweger et al., 2011
ceratobranchial 4 cartilage decreased size, abnormal standard conditions text only from Clément et al., 2008
ceratobranchial 5 bone apoptotic, abnormal standard conditions Fig. S8 with image from Wiweger et al., 2012
ceratobranchial 5 bone decreased length, abnormal standard conditions Fig. 4 with image from Wiweger et al., 2012
ceratobranchial 5 bone has fewer parts of type ceratobranchial 5 tooth, abnormal standard conditions Fig. 1 with imageFig. 2 with imageFig. 4 with image from Wiweger et al., 2012
ceratobranchial 5 bone malformed, abnormal standard conditions text only from Wiweger et al., 2011
ceratobranchial 5 bone ossified, abnormal standard conditions Fig. S2 with image from Wiweger et al., 2012
ceratobranchial 5 bone ossified, normal standard conditions text only from Wiweger et al., 2011
ceratobranchial 5 tooth attached to ceratobranchial 5 bone, normal standard conditions Fig. 2 with image from Wiweger et al., 2012
ceratobranchial 5 tooth decreased length, abnormal standard conditions Fig. 1 with imageFig. 4 with image from Wiweger et al., 2012
ceratobranchial 5 tooth increased thickness, abnormal standard conditions Fig. 4 with image from Wiweger et al., 2012
ceratobranchial 5 tooth increased width, abnormal standard conditions Fig. 1 with image from Wiweger et al., 2012
ceratobranchial 5 tooth mislocalised posteriorly, abnormal standard conditions Fig. 1 with image from Wiweger et al., 2012
ceratobranchial 5 tooth ossified, abnormal standard conditions Fig. 1 with imageFig. S2 with image from Wiweger et al., 2012
ceratohyal cartilage chondrocyte disorganized, abnormal standard conditions Fig. 3 from Wiweger et al., 2011
chondrocyte circular, abnormal standard conditions Fig. 3 from Wiweger et al., 2011
chondrocyte morphology, abnormal standard conditions Fig. 1 with imageFig. 6 with image from Clément et al., 2008
chondrocyte plasma membrane morphology, normal standard conditions Fig. 5 from Wiweger et al., 2011
chondrocyte intercalation involved in growth plate cartilage morphogenesis arrested, abnormal standard conditions Fig. 3 from Wiweger et al., 2011
cleithrum decreased size, abnormal standard conditions text only from Wiweger et al., 2011
cleithrum malformed, abnormal standard conditions text only from Wiweger et al., 2011
cranial cartilage deformed, abnormal standard conditions Table 2 from Wiweger et al., 2011
cranial cartilage shape, abnormal standard conditions Fig. 3 with image from Wiweger et al., 2014
cranial cartilage extracellular matrix composition, abnormal standard conditions Fig. 3Fig. 4 from de Andrea et al., 2011
Fig. 4 from Wiweger et al., 2011
cranial cartilage poly(ethylene imine) spatial pattern, abnormal standard conditions Fig. 3Fig. 4 from de Andrea et al., 2011
dermal bone hypoplastic, abnormal standard conditions text only from Wiweger et al., 2011
dilatator operculi increased width, abnormal standard conditions Fig. 3 with image from Wiweger et al., 2014
dilatator operculi shortened, abnormal standard conditions Fig. 3 with image from Wiweger et al., 2014
dorsomedial optic tract composition, abnormal standard conditions Fig. 4 with image from Trowe et al., 1996
fin decreased size, abnormal standard conditions Fig. for (to273b) from Phenotype Annotation (1994-2006)
fin fold pectoral fin bud absent, abnormal standard conditions Fig. 1 with image from Grandel et al., 2000
forebrain decreased size, abnormal standard conditions Table 1 from Trowe et al., 1996
glomerular basement membrane morphology, abnormal standard conditions Fig. 2 from Khalil et al., 2019
glomerular filtration process quality, normal standard conditions Fig. 3 from Khalil et al., 2019
glycosaminoglycan metabolic process disrupted, abnormal standard conditions Fig. 1 from Wiweger et al., 2011
head muscle increased width, abnormal standard conditions Fig. 3 with image from Wiweger et al., 2014
head muscle shortened, abnormal standard conditions Fig. 3 with image from Wiweger et al., 2014
heart anatomical region has extra parts of type muscle, abnormal standard conditions Fig. 3 with image from Wiweger et al., 2014
hyohyoideus absent, abnormal standard conditions Fig. 3 with image from Wiweger et al., 2014
inner ear increased size, abnormal standard conditions Table 3 from Whitfield et al., 1996
inner ear morphology, abnormal standard conditions Table 1 from van Eeden et al., 1996
inner ear quality, abnormal standard conditions Fig. for (to273b) from Phenotype Annotation (1994-2006)
inner ear structure, abnormal standard conditions Table 3 from Whitfield et al., 1996
interhyoideus increased width, abnormal standard conditions Fig. 3 with image from Wiweger et al., 2014
interhyoideus shortened, abnormal standard conditions Fig. 3 with image from Wiweger et al., 2014
levator arcus palatini increased width, abnormal standard conditions Fig. 3 with image from Wiweger et al., 2014
levator arcus palatini shortened, abnormal standard conditions Fig. 3 with image from Wiweger et al., 2014
mandibular arch skeleton decreased length, abnormal standard conditions Table 3 from Schilling et al., 1996
mandibular arch skeleton decreased size, abnormal standard conditions Table 4 from Schilling et al., 1996
mandibular arch skeleton increased thickness, abnormal standard conditions Table 3 from Schilling et al., 1996
mandibular arch skeleton morphology, abnormal standard conditions Fig. 1 from Khalil et al., 2019
Table 1 from Trowe et al., 1996
Table 1 from van Eeden et al., 1996
mandibular arch skeleton protruding, abnormal standard conditions Fig. 1 from Khalil et al., 2019
Meckel's cartilage increased size, abnormal standard conditions text only from Clément et al., 2008
mouth quality, abnormal standard conditions Fig. for (to273b) from Phenotype Annotation (1994-2006)
nervous system quality, abnormal standard conditions Fig. for (to273b) from Phenotype Annotation (1994-2006)
olfactory placode hypoplastic, abnormal standard conditions Table 1 from Trowe et al., 1996
opercle decreased size, abnormal standard conditions text only from Wiweger et al., 2011
opercle malformed, abnormal standard conditions text only from Wiweger et al., 2011
optic tract structure, abnormal standard conditions Table 1 from Karlstrom et al., 1996
ossification decreased occurrence, abnormal standard conditions Table 2 from Wiweger et al., 2011
ossification delayed, abnormal standard conditions Fig. 3 with imageFig. S2 with image from Wiweger et al., 2012
ossification process quality, abnormal standard conditions Fig. 2 with imageFig. 5 with image from Wiweger et al., 2014
pectoral fin absent, abnormal standard conditions Table 3 from Schilling et al., 1996
pectoral fin aplastic, abnormal standard conditions Fig. 1 with image from Grandel et al., 2000
Table 1 from Trowe et al., 1996
pectoral fin decreased size, abnormal standard conditions Fig. 3 from Volpi et al., 2017
Table 1Table 2 from van Eeden et al., 1996
pectoral fin quality, abnormal standard conditions Fig. for (to273b) from Phenotype Annotation (1994-2006)
pectoral fin bud hypoplastic, abnormal standard conditions Fig. 1 with image from Grandel et al., 2000
pectoral fin bud morphology, normal standard conditions text only from Grandel et al., 2000
pectoral fin development disrupted, abnormal standard conditions text only from van Eeden et al., 1996
pectoral fin endoskeletal disc absent, abnormal standard conditions Fig. 1 with image from Grandel et al., 2000
pectoral fin fold aplastic, abnormal standard conditions text only from van Eeden et al., 1996
pectoral girdle decreased size, abnormal standard conditions Fig. 1 with image from Grandel et al., 2000
pericardium edematous, abnormal standard conditions Fig. 1 from Khalil et al., 2019
pharyngeal arch 2 skeleton decreased length, abnormal standard conditions Table 3 from Schilling et al., 1996
pharyngeal arch 2 skeleton decreased size, abnormal standard conditions Table 4 from Schilling et al., 1996
Table 1 from Trowe et al., 1996
pharyngeal arch 2 skeleton increased thickness, abnormal standard conditions Table 3 from Schilling et al., 1996
pharyngeal arch 3-7 skeleton decreased length, abnormal standard conditions Table 3 from Schilling et al., 1996
pharyngeal arch 3-7 skeleton decreased size, abnormal standard conditions Table 4 from Schilling et al., 1996
Table 1 from Trowe et al., 1996
pharyngeal arch 3-7 skeleton increased thickness, abnormal standard conditions Table 3 from Schilling et al., 1996
pharyngeal arch 3-7 skeleton quality, abnormal standard conditions Fig. for (to273b) from Phenotype Annotation (1994-2006)
pharyngeal epithelium decreased thickness, abnormal standard conditions Fig. S3 with image from Wiweger et al., 2012
podocyte podocyte foot morphology, normal standard conditions Fig. 2 from Khalil et al., 2019
post-vent region curved dorsal, abnormal standard conditions Table 3 from Schilling et al., 1996
renal absorption process quality, normal standard conditions Fig. 3 from Khalil et al., 2019
retinal ganglion cell axon branched, abnormal standard conditions Fig. 4 with image from Trowe et al., 1996
retinal ganglion cell axon displaced, abnormal standard conditions Fig. 4 with image from Trowe et al., 1996
retinal ganglion cell axon fasciculation, abnormal standard conditions Fig. 4 with image from Trowe et al., 1996
retinal ganglion cell axon irregular spatial pattern, abnormal standard conditions Fig. 5 from Lee et al., 2004
retinal ganglion cell axon misrouted, abnormal standard conditions Table 1 from Karlstrom et al., 1996
retinal ganglion cell axon organization quality, abnormal standard conditions Fig. 4 with image from Trowe et al., 1996
retinal ganglion cell axon guidance disrupted, abnormal standard conditions Fig. 5 from Lee et al., 2004
retinal ganglion cell axon guidance process quality, abnormal standard conditions Table 1 from Karlstrom et al., 1996
Fig. 4 with image from Trowe et al., 1996
retinal ganglion cell axon guidance quality, abnormal standard conditions Fig. for (to273b) from Phenotype Annotation (1994-2006)
sensory system quality, abnormal standard conditions Fig. for (to273b) from Phenotype Annotation (1994-2006)
skeletal system development disrupted, abnormal standard conditions Fig. 5 with image from Clément et al., 2008
sternohyoid increased width, abnormal standard conditions Fig. 3 with image from Wiweger et al., 2014
sternohyoid shortened, abnormal standard conditions Fig. 3 with image from Wiweger et al., 2014
surface structure quality, abnormal standard conditions Fig. for (to273b) from Phenotype Annotation (1994-2006)
swim bladder uninflated, abnormal standard conditions Fig. 1 from Khalil et al., 2019
tectal neuropile reln expression decreased amount, abnormal standard conditions Fig. 4 with image from Di Donato et al., 2018
tooth mineralization delayed, abnormal standard conditions Fig. 3 with imageFig. S2 with image from Wiweger et al., 2012
ventral intermandibularis anterior increased width, abnormal standard conditions Fig. 3 with image from Wiweger et al., 2014
ventral intermandibularis anterior shortened, abnormal standard conditions Fig. 3 with image from Wiweger et al., 2014
ventral intermandibularis posterior increased width, abnormal standard conditions Fig. 3 with image from Wiweger et al., 2014
ventral intermandibularis posterior shortened, abnormal standard conditions Fig. 3 with image from Wiweger et al., 2014
whole organism curved, abnormal standard conditions Fig. 1 from Khalil et al., 2019
whole organism dead, abnormal standard conditions text only from Grandel et al., 2000
whole organism lacks all parts of type pectoral fin, abnormal standard conditions Fig. 1 from Khalil et al., 2019
whole organism lethal (sensu genetics), abnormal standard conditions Fig. for (to273b) from Phenotype Annotation (1994-2006)
whole organism anterior-posterior axis decreased length, abnormal standard conditions Table 2 from Wiweger et al., 2011

CITATIONS  (23)