ZFIN Fish: knu3Tg

ZFIN ID: ZDB-FISH-150901-19290

Fish name:	knu3Tg
Genotype:	knu3Tg
Targeting Reagent:	none

HUMAN DISEASE MODELED by knu3Tg

Human Disease	Conditions	Citations
glioblastoma	cancer xenotransplantation	Pudelko et al., 2018

GENE EXPRESSION
Gene expression in knu3Tg

RNA expression

Expressed Gene	Structure	Conditions	Figures
atoh1a	hindbrain	standard conditions	Fig 1 from Belzunce et al., 2020
atoh1b	hindbrain	standard conditions	Fig 1 from Belzunce et al., 2020
cxcr4b	epiphysis epithalamus habenula	standard conditions	Fig. 1 , Fig. 2 , Fig. 3 from Roussigné et al., 2009
cxcr5	telencephalon radial glial cell	control	Fig. S2 from Kizil et al., 2012
	telencephalon radial glial cell	physical alteration: anatomical structure	Fig. S2 from Kizil et al., 2012
dla	neuron photoreceptor cell	standard conditions	Fig. 2 from Cau et al., 2008
dlb	midbrain neuron	standard conditions	Fig. 3 from Dyer et al., 2014 Fig. 2 from Cau et al., 2008
dld	neuron	standard conditions	Fig. 2 from Cau et al., 2008
flt1	spinal cord motor neuron spinal cord interneuron	standard conditions	Fig. 5 from Krueger et al., 2011
isl1a	epiphysis neuron	standard conditions	Fig. 4 , Fig. 5 from Cau et al., 2008
kctd12.1	habenula	standard conditions	Fig. 1 from Roussigné et al., 2009
lhx3	neuron	standard conditions	Fig. 1 from Cau et al., 2008
map2k5	neuron	standard conditions	Fig. S11 from Jo et al., 2017
neurod1	epiphysis	standard conditions	Fig. 4 from Quillien et al., 2011
neurog1	habenula midbrain	standard conditions	Fig. 5 from Dyer et al., 2014 Fig. 2 from Roussigné et al., 2009
otx5	epiphysis	standard conditions	Fig. 4 from Quillien et al., 2011
pou4f1	habenula	standard conditions	Fig. 1 from Roussigné et al., 2009
vegfaa	retina neuron	standard conditions	Fig. 1 from Madelaine et al., 2017

Protein expression

Antibody	Antigen Genes	Structure	Conditions	Figures
Ab3-snap25		posterior lateral line ganglion neuron	control	Fig. S1 from Fontenas et al., 2016
zpr-1		epiphysis photoreceptor cell	standard conditions	Fig. 3 from Quillien et al., 2011 Fig. 1 , Fig. 5 from Cau et al., 2008
Ab1-tcf7l2		dorsal habenular nucleus neuron	standard conditions	Fig. 4 from Hüsken et al., 2014
Ab2-isl	isl1a	epiphysis neuron pineal complex neuron	standard conditions	Fig. 4 from Pavlou et al., 2014 Fig. 4 , Fig. 5 from Cau et al., 2008

Reporter gene expression

Expressed Gene	Structure	Conditions	Figures
EGFP	amacrine cell brain central nervous system dorsal habenular nucleus neuron dorsal thalamus neuron enteric nervous system epiphysis epithalamus habenula head hindbrain neuron medial longitudinal fasciculus mesencephalic nucleus of trigeminal nerve midbrain midbrain hindbrain boundary motor neuron axon nervous system neuron nucleus of the caudal commissure optic tectum pineal complex neuron posterior lateral line ganglion posterior lateral line nerve posterior lateral line neuromast axon terminus retina neuron retinal ganglion cell layer retinal inner plexiform layer spinal cord neuronal cell body spinal cord interneuron telencephalon (not) ventral thalamus	standard conditions	54 figures from 37 publications
	enteric nervous system epithalamus hindbrain neuron neuron pineal complex neuron spinal cord neuron	chemical treatment: Cyclopamine	Fig. 1 from Araya et al., 2014 Fig. 1 , Fig. 2 from Dozawa et al., 2014 Fig. 5 from Pavlou et al., 2014 Fig. 6 from Rodríguez-Aznar et al., 2013 Fig. 6 from Roussigné et al., 2009 Fig. 5 from Reichenbach et al., 2008
	neuron spinal cord telencephalon neuron	physical alteration: anatomical structure	Fig. 2 from Briona et al., 2014 Fig. 2 from Palha et al., 2013 Fig. S2 from Kizil et al., 2012 Fig. 1 from Kizil et al., 2012

PHENOTYPE
Phenotype in knu3Tg

Phenotype	Conditions	Figures
brain central nervous system tumor increased amount, abnormal	cancer xenotransplantation	Fig. 1 from Pudelko et al., 2018
habenula determination of left/right symmetry disrupted, abnormal	chemical treatment: pharmaceutical	Fig. 6 from Roussigné et al., 2009
habenula neurogenesis delayed, abnormal	chemical treatment: pharmaceutical	Fig. 6 from Roussigné et al., 2009
habenula neurogenesis process quality, abnormal	chemical treatment: pharmaceutical	Fig. 6 from Roussigné et al., 2009
neural tube morphology, abnormal	chemical treatment: pharmaceutical	Fig. 1 from Araya et al., 2014
neuron amount, normal	control	Fig. 4 from Gribble et al., 2007
neuron amount, normal	chemical treatment: Cyclopamine	Fig. 4 from Gribble et al., 2007
nodal signaling pathway involved in determination of left/right asymmetry disrupted, abnormal	chemical treatment: pharmaceutical	Fig. 6 from Roussigné et al., 2009
primary neuron proliferative, abnormal	chemical treatment: messenger RNA	Fig. 6 from Rodríguez-Aznar et al., 2013
proliferative region mislocalised, abnormal	chemical treatment: messenger RNA	Fig. 6 from Rodríguez-Aznar et al., 2013
re-entry into mitotic cell cycle increased occurrence, abnormal	chemical treatment: messenger RNA	Fig. 6 from Rodríguez-Aznar et al., 2013
regulation of neural precursor cell proliferation decreased process quality, abnormal	chemical treatment: messenger RNA	Fig. 6 from Rodríguez-Aznar et al., 2013

CITATIONS (90)