Engineered Region

LEXPR

ID
ZDB-EREGION-120411-1
Name
LEXPR
Symbol
LEXPR
Previous Names
  • LPR
Location
Unmapped
Note
LEXPR: a transactivator that is a fusion of the DNA-binding domain of the bacterial LexA protein (residues 1-87), the truncated ligand-binding domain of the human progesterone receptor (residues 640-914) and the activation domain of the human p65 (residues 283-551). Upon activation by mifepristone (aka RU486) LEXPR binds to the operator-promoter and induces transcription.
Constructs
Citations
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