Znomics, Inc.
Contact Person:
No Contact Person Assigned
Email: info@znomics.com
Address: Suite 200 2611 SW 3rd Avenue Portland, OR 97201 USA
Country: United States
Phone: (503) 827-5270
Fax: (503) 228-3290
Line Designation: zm

Znomics is a biotechnology company utilizing proprietary zebrafish technologies to uncover new drug targets and pharmaceuticals to treat complex human diseases. The company has developed a novel drug discovery methodology based on high throughput, in vivo drug screening against human disease models in zebrafish. This methodology screens against all potential drug targets in the animal and improves the speed and efficacy of finding lead compounds, as compared with the single target screens traditionally used in the pharmaceutical industry.

Znomics' new drug discovery approach is based on the ZeneMark® Library, the Company's proprietary database of retroviral mutations in the zebrafish. The ZeneMark Library currently contains more than 11,000 strains of fish representing mutations in more than half of the known zebrafish genes. The Company is leveraging this technology for its internal drug discovery efforts, as well as building collaborative alliances with pharmaceutical companies and universities. The Company also provides mutant fish strains to university scientists, for research purposes.

Golling, Greg

Silic, M.R., Wu, Q., Kim, B.H., Golling, G., Chen, K.H., Freitas, R., Chubykin, A.A., Mittal, S.K., Zhang, G. (2020) Potassium Channel-Associated Bioelectricity of the Dermomyotome Determines Fin Patterning in Zebrafish. Genetics. 215(4):1067-1084
Song, Y., Golling, G., Thacker, T.L., and Cone, R.D. (2003) Agouti-related protein (AGRP) is conserved and regulated by metabolic state in the zebrafish, Danio rerio. Endocrine. 22(3):257-266
Golling, G., Amsterdam, A., Sun, Z., Antonelli, M., Maldonado, E., Chen, W., Burgess, S., Haldi, M., Artzt, K., Farrington, S., Lin, S.Y., Nissen, R.M., and Hopkins, N. (2002) Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development. Nature Genetics. 31(2):135-140
Chen, W.B., Burgess, S., Golling, G., Amsterdam, A., and Hopkins, N. (2002) High-throughput selection of retrovirus producer cell lines leads to markedly improved efficiency of germ line-transmissible insertions in zebra fish. Journal of virology. 76(5):2192-2198
Amsterdam, A., Burgess, S., Golling, G., Chen, W., Sun, Z., Townsend, K., Farrington, S., Haldi, M., and Hopkins, N. (1999) A large-scale insertional mutagenesis screen in zebrafish. Genes & Development. 13(20):2713-2724