Genomic Feature
m477
- ID
- ZDB-ALT-980203-771
- Name
- m477
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Driever Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 3: 28837730 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A at position 798 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Tyr>Stop at position 266 (1)
- Flanking Sequence
-
TTTATGCAGCAGATGCCCTTCCAGCCGTAACCCAATCTCTGGGAAACACCCATACATACTCAATCACACACATACACTACGGCCAATTTAGCTTACCCAATTCACCTATACTGCATGTCTTTGGACTTGTGGGGGAAACCGGAGCACCCGAAGGAAACCCTCACGAACACAGTGAGAACATGCAAACTCCGTACAGAAACGCCAGCTGACCCAGCCGAGGCGATAGTGGTAGTGGGTAGTGCCACCGCTTCACCCTCTTTACAAACATTTTAGAGAATAAGAGATCTGGACTTTCTACAGTGAGACAGAATTTAAAAATATCTCCATTCGTGCTCTGAAGATAAACAAAAGTCTTATAGGTTTGTAATGTATTGAGCATGAGTAAATGATGAACAACCAGAGTCTTTTACTAATTAGATTTCAGTTAGCTAACATAAGTTTTGTAGCACTTATGTAATTAAAAAATGTAATTGAGAAATATATTTAAATCTATTTGCAGA
T/A GCTGCAGCACAGGAAGCACTGACGGACATGCCTCCCAGATCAGAAGAGGTAATAAAATGTTCACTCCTAAAATGTTACCATTTTTATTCAAATGTGTTTTTAATTTATTCATTTTTTATAAATTGGCACACTGCTTCCACATACATACATGCATTTTTTTGTTCTATTCAATTATGTTGTAATAAAGAGATGCTATGTCGTTAAACTGTACTTTACCATAATAAAACAATACTATGCAGGTAAAAAAGTTTTCTCACAAAGCTGACATATTATGCCATGAAAATATTCACACATTATGCATATTCATGTTATTCACACAATTGAAAGAAAAAAATTATTAAATTCGTGACATGACAACATTGGCCTATTTCCTATGCAATATATAAAATATATATTTAAAAAAAAAAAAACGGATACATAGACAAATATATTTTATATGCCATATAAAACTATTGGCATGGTGAATGTGTTTGGCAAGAGCCATGGCCCAGACAGAATCT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| ift70m477/m477 | Homozygous | ♀+/- ♂+/- | 5 figures  from 3 publications | Fig. 1 from Hellman et al., 2010 | |
| ift70m477/m477 (AB/TU) | Homozygous | ♀+/- ♂+/- | 5 figures from 2 publications | ||
| ift70m477 (AB) | Unknown | Unknown | 4 figures from 2 publications | ||
| ift70m477/+ + MO2-b9d2 | Complex | Fig. S4 from Zhao et al., 2011 | |||
| ift70m477; kif3asa1617 | Complex | Fig. 4 from Pooranachandran et al., 2016 |
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Supplemental Information
- Genotyping protocol
- None
- Pooranachandran, N., Malicki, J.J. (2016) Unexpected Roles for Ciliary Kinesins and Intraflagellar Transport Proteins. Genetics. 203(2):771-85
- Pathak, N., Austin, C.A., and Drummond, I.A. (2011) Tubulin tyrosine ligase like genes TTLL3 and TTLL6 maintain zebrafish cilia structure and motility. The Journal of biological chemistry. 286(13):11685-11695
- Zhao, C., and Malicki, J. (2011) Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos. The EMBO journal. 30(13):2532-2544
- Hellman, N.E., Liu, Y., Merkel, E., Austin, C., Le Corre, S., Beier, D.R., Sun, Z., Sharma, N., Yoder, B.K., and Drummond, I.A. (2010) The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch. Proceedings of the National Academy of Sciences of the United States of America. 107(43):18499-18504
- Pathak, N., Obara, T., Mangos, S., Liu, Y., and Drummond, I.A. (2007) The Zebrafish fleer Gene Encodes an Essential Regulator of Cilia Tubulin Polyglutamylation. Molecular biology of the cell. 18(11):4353-4364
- Tsujikawa, M., and Malicki, J. (2004) Genetics of photoreceptor development and function in zebrafish. The International journal of developmental biology. 48(8-9):925-934
- Doerre, G. and Malicki, J. (2002) Genetic analysis of photoreceptor cell development in the zebrafish retina. Mechanisms of Development. 110(1-2):125-138
- Malicki, J. (2000) Harnessing the power of forward genetics – analysis of neuronal diversity and patterning in the zebrafish retina. Trends in neurosciences. 23(11):531-541
- Drummond, I.A., Majumdar, A., Hentschel, H., Elger, M., Solnica-Krezel, L., Schier, A.F., Neuhauss, S.C., Stemple, D.L., Zwartkruis, F., Rangini, Z., Driever, W., and Fishman, M.C. (1998) Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function. Development (Cambridge, England). 125:4655-4667
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