Genomic Feature
m662
- ID
- ZDB-ALT-980203-561
- Name
- m662
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Driever Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 4: 4723008 (GRCz11) (1) Details
- Nucleotide change
- G/C
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>G (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Lys>Asn at position 301 (1)
- Flanking Sequence
-
ATGTGCCTTATTTATGAAGTTTAAAATAAAAATAAAAATATTTTAAGCTCATGAGTATATTTAAAATATATATTTTTTACCAAATTTCATATGACTTCTGAATTATTGAGATAATATTTCACTCGCAAAATAGGTTTAATTAAATTTAATGTATATAATGCCATATACTGTATAAAACAGGCCTGTTTTAATTTTGCATTGTTAAATAGAAAATAAAGTAATAAATAATTTGAAATGCACCAGAAAATCTGACCATTCACATGTACTTAATAAACATAACATTTATAACCCTATCACAAACCAAACCATCGCTCAGACTTACTTCTTCTCTAAGGCATCCACATACTCTTTCTTTTTCCTGCGACTCTCCTGTGCTGAAATCTGATGGAGAAATAAATGTTGAATATAGACATTAGCTGTAATACTTCTCTTAAAAATATGCATCATCATCTTACAGTAATACCATATTAATGAATGTGCTGAAACATGACACTCACCTT
G/C TTCTTGATCTTTCTGCGGATCTTCTTCAGTGCTTTCTCCTCAGCCTTGGACAGGGGCAGTTTGGTGGGCACGGGGTATCCTTCAGCAATGAGGGTCCTTTTCTCCTCCTCGGTCAATAAAAGGGGACCAGAGCCCTGCAGTTTCTGTCAAAACAGATGAATTTTTAATTTAATTTTTAAACATATATTTTTTTTAAATAGCATAGAAAAATGGAAGAAAAAAACCACCCAGAAAATATTAAATAGAAATAAAATAAAAAAAGGGATTGTTCGCGTTAACAAGATCAAAGTAAATAAATAATAACGATAATATGTATATATATATATATATATATATATATATATATATATATATAAAATATAAAAATATAAGTATAAATATTAGCAACCCTGTTTATTTGTAGACTATCGGAAAAAAAATTAGCCTTAAGGGGCTAATAATTTTGACCTTAAAATGGTGTTTAAAAATTTTGAAACTGCTTTTATTCAAGTCGAAATAAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| creb3l2m662/m662 (AB) | Homozygous | ♀+/- ♂+/- | 5 figures  from 2 publications | Fig. 7 from Melville et al., 2011 | |
| creb3l2m662/+ (AB) | Heterozygous | Unknown | |||
| creb3l2m662 (AB) | Unknown | Unknown | Fig. for (m662) from Phenotype Annotation (1994-2006) |
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Supplemental Information
- Genotyping protocol
- None
- Melville, D.B., Montero-Balaguer, M., Levic, D.S., Bradley, K., Smith, J.R., Hatzopoulos, A.K., and Knapik, E.W. (2011) The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis. Disease models & mechanisms. 4(6):763-76
- Driever, W., Solnica-Krezel, L., Schier, A.F., Neuhauss, S.C., Malicki, J., Stemple, D.L., Stainier, D.Y., Zwartkruis, F., Abdelilah, S., Rangini, Z., Belak, J., and Boggs, C. (1996) A genetic screen for mutations affecting embryogenesis in zebrafish. Development (Cambridge, England). 123:37-46
- Neuhauss, S.C., Solnica-Krezel, L., Schier, A.F., Zwartkruis, F., Stemple, D.L., Malicki, J., Abdelilah, S., Stainier, D.Y., and Driever, W. (1996) Mutations affecting craniofacial development in zebrafish. Development (Cambridge, England). 123:357-367
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