Genomic Feature
m86
- ID
- ZDB-ALT-980203-405
- Name
- m86
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Driever Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 2: 35939841 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Tyr>Stop at position 131 (1)
- Flanking Sequence
-
CACTGAAAGCATATGTTCTGTTTTGAGGAGGTTTTTTGGTATTGGACTTTGAAGGAGCCACCCTGTTGCTGTGAAAGGATGGAGGATGAGGAAGCTCTCTAATCTAAAACTTCTTTGTTTGTATTCTGATGATTAATAGTGGTCTCAGAGGATTGAAACAACATGTGGGCAAGTAATAATAACAACAGAATTTTCTTTTTTGGGTGAACTAACACTTTAAGTTCAAACTAAGCTGCATTATTTTCCATTTGCACTGCTTTTGGTAGATTGAGTTAGTCTTTCTGTAGCAAATGATACTATTTATTAATAGAGGAGGTCGAAATTTCCACTTTCTGTGCTTTTATGAGATTATGTGCTTCATAAATCTAAATGGTCCATCTAGTTCAGCTATTTATGGTGTAAAATTGTCAGGTTTTTGATATATTTTGTGAAACACAATGAATGAAGATAACTCATATCACCTTCTTTCATCTTCTAGGCAAATCTTTCGACATCACCTA
T/A GTGCGTTTGAAGTTCCACACCAGCCGTCCTGAGAGTTTTGCCATCTACAAGCGCTCCAGTGAAGACGGGCCTTGGACCCCCTACCAATACTACAGTGGCTCCTGTGAAAAAACCTACAGCAAAAACAACCGTGGCTTCATCCGCACAGGCGAGGACGAGCAGCAGGCTCTGTGTACAGATGAGTTTAGCGACATCTCGCCACTCTATGGAGGAAACGTGGCTTTCTCTACGCTCGAGGGCCGACCCAGTGCATATAACTTCGACAACAGCCCTGTACTGCAGGTCAGAGCTTTTCTATCTCTCTGTCTTTCTTTGTGATCTCTCCTTTGATCACTCACTTTCACTTAACGTGATTTAAACTCACTCATGAAGTCAAAAGTGATTCCCATCATTTACTGTTTCAAACAAATTTACTGGTGGGAATCAAAATTGCACTCTCCAGATGTGTGGTTGTGCAGTAATGCGTGATTGCAGCCAACTTACTTTTCCAAGACTTCTTT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| lamc1m86/m86 | Homozygous | ♀+/- ♂+/- | 6 figures  from 3 publications | Fig. S1 from Gutzman et al., 2008 | |
| lamc1m86/m86 (AB) | Homozygous | ♀+/- ♂+/- | 4 figures from 4 publications | 2 figures from 2 publications |
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Supplemental Information
- Genotyping protocol
- None
- Falat, E.J., Voit, G.C., Gutzman, J.H. (2022) Laminin-111 mutant studies reveal a hierarchy within laminin-111 genes in their requirement for basal epithelial tissue folding. Developmental Biology. 492:172-186
- Gutzman, J.H., Graeden, E., Brachmann, I., Yamazoe, S., Chen, J.K., Sive, H. (2018) Basal constriction during midbrain-hindbrain boundary morphogenesis is mediated by Wnt5b and focal adhesion kinase. Biology Open. 7(11):
- Nicolás-Pérez, M., Kuchling, F., Letelier, J., Polvillo, R., Wittbrodt, J.,Martínez-Morales, J.R. (2016) Analysis of cellular behavior and cytoskeletal dynamics reveal a constriction mechanism driving optic cup morphogenesis. eLIFE. 5
- Ivanovitch, K., Cavodeassi, F., and Wilson, S.W. (2013) Precocious acquisition of neuroepithelial character in the eye field underlies the onset of eye morphogenesis. Developmental Cell. 27(3):293-305
- Lowery, L.A., De Rienzo, G., Gutzman, J.H., and Sive, H. (2009) Characterization and Classification of Zebrafish Brain Morphology Mutants. The Anatomical record. 292(1):94-106
- Gutzman, J.H., Graeden, E.G., Lowery, L.A., Holley, H.S., and Sive, H. (2008) Formation of the zebrafish midbrain-hindbrain boundary constriction requires laminin-dependent basal constriction. Mechanisms of Development. 125(11-12):974-983
- Coutinho, P., Parsons, M.J., Thomas, K.A., Hirst, E.M., Saude, L., Campos, I., Williams, P.H., Stemple, D.L. (2004) Differential Requirements for COPI Transport during Vertebrate Early Development. Developmental Cell. 7(4):547-558
- Tsujikawa, M., and Malicki, J. (2004) Genetics of photoreceptor development and function in zebrafish. The International journal of developmental biology. 48(8-9):925-934
- Parsons, M.J., Pollard, S.M., Saude, L., Feldman, B., Coutinho, P., Hirst, E.M., and Stemple, D.L. (2002) Zebrafish mutants identify an essential role for laminins in notochord formation. Development (Cambridge, England). 129(13):3137-3146
- Karlstrom, R.O., Trowe, T., and Bonhoeffer, F. (1997) Genetic analysis of axon guidance and mapping in the zebrafish. Trends in neurosciences. 20(1):3-8
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