Genomic Feature
t1
- ID
- ZDB-ALT-980203-1829
- Name
- t1
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 1: 47416639 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Arg>Stop at position 68 (1)
- Flanking Sequence
-
GTGCACATACTTCCTCAACTGCTTCCATGCCAAATGATACAGTTCCACGATACTAAGCAGCAGTGACACCGCTGCTACTGCTAGCATGAAGACAATGAACACGTTCTTCTCTGTTGGTCTGGAGATGTAGCAGTTGACCGGATGTGGACACGGAGGGGCTTTACACACATAGAGTGCACTAAGGAAGACTCCGTAGATCAGGTACTGGATTATGATGAAGATCACTTCCATCACAGTGCGGATGAGGATGCTGAGGACGTATGTTTGCAGCAACGCACCCTTCAATCGTACCCTCCTACCTCCACCTTCGTCCTCCTTGTTCTTGTCATCTTCTGGGTACTTTTCTCCATCTCTCTGCGCTCCTTCATCATCCAGCTCTTTCCTCTTCTTCTCCTCTCGGCGGACGATATGCATTGCGTGCCCCATGTAGATCAGAGAAGGTGTAGACACGAACACGATCTGGAGCACCCAGAAGCGTATATGCGCTATAGGAAAGGCTC
G/A GTCGTAACAAACGTTCTCGCAGCCGGGCTGCTCTGTGTCGCAGGTGAAGTCTTCCTGCTCGTCCCCCCACGAGGATTCAGCAGCCGTGCCTAGTACCAAGATCCGGAAGATGAAAAGAATAGTGAGCCACACCTTTCCCACCGAGGTTGAATGCTCCTGGACTTCTTCTAGAAAGTTCCCCAGCAGACTCCAGTCGGCCATGCCTATTCAGAGGAGCCTGAGGTGGAAATAAGAGGTAGTGTGAATGGAAGGGAGAAAGTAACCGTTTTATACAATGATTTGCCTAATTAGCCTAATTTGCCCAATTAACCTACAGTTGAAGTCAGAATTATTAGCCCCCCTTTGCATTTTTTTTCTTTTTTAAATATTTCCCAGATAATGATCAACAGAGCAAGGAAATTTTCACAGTATGTCTGATAATATTTTTTTCTTCTGGAGAAAGTCTTATTTGTTTTATTTTGGCTAAAATAAAAGCAGTTTTACATTTTTTGAAGCCCATT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| gja5bt1/t1 | Homozygous | ♀+/- ♂+/- | 9 figures  from 6 publications | ||
| gja5bt1/t1 | Homozygous | Unknown | 5 figures from 2 publications | Fig. 5 from Cacialli et al., 2021 | |
| gja5bt1/t1 (TU) | Homozygous | ♀+/- ♂+/- | Fig. 1 from Frohnhöfer et al., 2016 | ||
| gja5bt1/+ (AB) | Heterozygous | Unknown | 2 figures from Haffter et al., 1996 | ||
| gja5bt1 | Unknown | Unknown | Fig. for (t1) from Phenotype Annotation (1994-2006) | Fig. S3 from Watanabe et al., 2006 | |
| gja5bt1 (TL) | Unknown | Unknown | |||
| gja5bdtk3/+; gja5bt1/+ | Complex | Fig. 1 from Irion et al., 2014 | |||
| gja5bt1/t1; ou2001Tg | Complex | Fig. 1 from Watanabe et al., 2012 | |||
| gja5bt1/t1; ou2002Tg | Complex | Fig. 2 from Watanabe et al., 2012 | |||
| gja5bt1/t1; ou2008Tg | Complex |
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Supplemental Information
- Genotyping protocol
- None
- Cadete, F., Francisco, M., Freitas, R. (2023) Bmp-signaling and the finfold size in zebrafish: implications for the fin-to-limb transition. Evolution; international journal of organic evolution. 77(5):1262-1271
- Saralahti, A.K., Harjula, S.E., Rantapero, T., Uusi-Mäkelä, M.I.E., Kaasinen, M., Junno, M., Piippo, H., Nykter, M., Lohi, O., Rounioja, S., Parikka, M., Rämet, M. (2023) Characterization of the innate immune response to Streptococcus pneumoniae infection in zebrafish. PLoS Genetics. 19:e1010586e1010586
- Gonçalves, C., Kareklas, K., Teles, M.C., Varela, S.A.M., Costa, J., Leite, R.B., Paixão, T., Oliveira, R.F. (2022) Phenotypic architecture of sociality and its associated genetic polymorphisms in zebrafish. Genes, brain, and behavior. 21(5):e12809
- Cacialli, P., Mahony, C.B., Petzold, T., Bordignon, P., Rougemont, A.L., Bertrand, J.Y. (2021) A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress. Nature communications. 12:4484
- Castro, J., Beviano, V., Paço, A., Leitão-Castro, J., Cadete, F., Francisco, M., Freitas, R. (2021) Hoxd13/Bmp2-mediated mechanism involved in zebrafish finfold design. Scientific Reports. 11:7165
- Eom, D.S., Patterson, L.B., Bostic, R.R., Parichy, D.M. (2021) Immunoglobulin superfamily receptor junctional adhesion molecule 3 (Jam3) requirement for melanophore survival and patterning during formation of zebrafish stripes. Developmental Biology. 476:314-327
- Evsiukova, V.S., Bazovkina, D., Bazhenova, E., Kulikova, E.A., Kulikov, A.V. (2021) Tryptophan Hydroxylase 2 Deficiency Modifies the Effects of Fluoxetine and Pargyline on the Behavior, 5-HT- and BDNF-Systems in the Brain of Zebrafish (Danio rerio). International Journal of Molecular Sciences. 22(23):
- McCluskey, B.M., Uji, S., Mancusi, J.L., Postlethwait, J.H., Parichy, D.M. (2021) A complex genetic architecture in zebrafish relatives Danio quagga and D. kyathit underlies development of stripes and spots. PLoS Genetics. 17:e1009364
- Stewart, S., Le Bleu, H.K., Yette, G.A., Henner, A.L., Robbins, A.E., Braunstein, J.A., Stankunas, K. (2021) longfin causes cis-ectopic expression of the kcnh2a ether-a-go-go K+ channel to autonomously prolong fin outgrowth. Development (Cambridge, England). 148(11):
- Audira, G., Siregar, P., Strungaru, S.A., Huang, J.C., Hsiao, C.D. (2020) Which Zebrafish Strains Are More Suitable to Perform Behavioral Studies? A Comprehensive Comparison by Phenomic Approach. Biology. 9(8)
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