Genomic Feature
ty121
- ID
- ZDB-ALT-980203-1668
- Name
- ty121
- Synonyms
-
- Y121A (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 8: 21362148 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Leu>Gln at position 305 (1)
- Flanking Sequence
-
ACCTTTCTCAACAATACAGAAAAAGATACAATTATGTAACTATTTGCTAGTTTATTAAATTTTTAGATAATATTTTTCCTGTGATGTGATAACATGGCAAAGGTCTTGTTTTATTTATTCATTTATTTCAGAAAATAATTCAATCATTTTATAAAAACAATTCTCTTTTTAATGATCAAAATCCTTTGTTTTTATTTTAAAACAATTAAAATAGTTGTTTTCTTTTCAACAGTTTATTAGGAAACTTAGATAAATAGCAAGTAAAAATCTTTGTAACATTATAAATAAATGAATTTATTTATTTTAAAACAATTGGTTTTTATTTACTGACAGCAAACTTTTGGATGCTAGAATATCTTCTGAAATGACACTAAAAATGTGTTCTGTCTGCAAAGGTTGTGAGATCTACTCAGACATGGGCAATCATGCCTCCATGATCCAGGGCATCAGAAACAGTGGGGCCAAACGTTTCATTTTCCGACACAATGATGCCAGCCATC
T/A GGAGGAACTGCTGAGCCGCTCAGATCCACTGACCCCCAAAATCGTGGCCTTCGAGACTGTGCATTCAATGGATGGTGAGTTAAATATAGGACCACATAAGTACTTCAAAGGAGCTGTTTCTCCTTCTTAAACACTATGTCATGGGTTTAATTCAGAGTGTAAAGCCTGAATGCAATCTGATAACAAGTAAGTGAAGTTTATTTATAACTAATTTCGAGAACCACATAGTTATGATTGACCTCGGCTGGTCTCGCATTAGCAATCACAAATATATATATACCAATCAATATACCAATACTGATATACCAATCAGATAAATCCAAATGCATATGCAGTTGAAGTCATAATTATAGCCCCCCTGAATTATCCCCCCTCGTTTAATTTTTTCTCCAATTTCTGCTTAAAGGAGATATTTTTTCAACACATTTCTAAACATAATAGTTTTAATAACTTATCTCTAATAACGGATTTATTTTATCTTTGCCATCATGACAATAAAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| alas2ty121/ty121 | Homozygous | Unknown | 3 figures  from 2 publications | ||
| alas2ty121/ty121 | Homozygous | ♀+/- ♂+/- | Table 1 from Oates et al., 1999 |
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Supplemental Information
- Genotyping protocol
- None
- Pratt, S.J., Drejer, A., Foott, H., Barut, B., Brownlie, A., Postlethwait, J., Kato, Y., Yamamoto, M., and Zon, L.I. (2002) Isolation and characterization of zebrafish NFE2. Physiological Genomics. 11(2):91-98
- Oates, A.C., Brownlie, A., Pratt, S.J., Irvine, D.V., Liao, E.C., Paw, B.H., Dorian, K.J., Johnson, S.L., Postlethwait, J.H., Zon, L.I., and Wilks, A.F. (1999) Gene duplication of zebrafish JAK2 homologs is accompanied by divergent embryonic expresssion patterns: only jak2a is expressed during erythropoiesis. Blood. 94(8):2622-2636
- Brownlie, A., Donovan, A., Pratt, S.J., Paw, B.H., Oates, A.C., Brugnara, C., Witkowska, H.E., Sassa, S., and Zon, L.I. (1998) Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia. Nature Genetics. 20:244-250
- Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
- Ransom, D.G., Haffter, P., Odenthal, J., Brownlie, A., Vogelsang, E., Kelsh, R.N., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Mullins, M.C., and Nüsslein-Volhard, C. (1996) Characterization of zebrafish mutants with defects in embryonic hematopoiesis. Development (Cambridge, England). 123:311-319
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