Genomic Feature
ta53c
- ID
- ZDB-ALT-980203-1513
- Name
- ta53c
- Synonyms
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 3: 16689211 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>A in Acceptor Splice Site of Intron 23 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
CAAGATAATAAAAAGAAAGAAAATCATGAAATGTAAACACAAAATGAACAAAGCAAACCTCCTTTTGATAGAGCTCAGATTCTCTCTTTTTGCAGAAGTCGCATACAGCCACTGTGAAGAAAACAAATTAAATAAATGACAATAACGTAGTACTACAGAGCAGAGTTTCCCAACCCTGTTCCTGAAAGCACACCAACAGTACACATTTTCAACCTCTTCCTATTTAAACATCATCAGAACATTAAAGGGAAATTAAAAACCTGAAATGAATGGGGCAGATAAGGGAGACATCCAAAATATTCACTATTGGTGTGCCTCCGGGAACAGGGTTAGGCTATAGAGTACTGCCGATTTCCTCAACAAACACACACACACTAGATACACACCATCGGTTTTCAGCACAGCTCTGCAGCCGATGCAAGTGCTTCGTTTCTGAGCGAAAGCCATGAGACCACCGACTCGGGAGGTCAAGACCGTCTTACAGCGGGTGTGATCTCCCT
C/T TGAAACAACACCGAGCAAAAACAGGTAAGAGTTTGCAATAGGGTTGCATGATATTGGAAAAAAATAAACTGACATTGCGATACTGAGTTTTTCTGCGATACGTATGAATATAATTTAACCCGATGACTTCAACAGCTCTATTTGGAAAGATTTAGATTGATTGGGATGATTTTCTATGGGAATGAATCTGCATAAATATAAGAAACATTGGTAAACACAAAAGAGAAAAAAAATATACAAAGCAATTTATAGTTTTCTGAGGAGTCTAAATTTGGCTTCACACCATGGGCGGAGCTTGGAGGGGTGCTTCCCCCCCCCATTGGCTAAAATAAGTTGCACAAAATTATTCAATATTAACTTAGGCTTTCTATTTAAATAAGAATTATTAGTTTACTTTGTAAATAAATTCAAATAAACATATAACCTTATAATTAAAAAATTTAAGCGAAGCGCAAAACATCCTGTGAGTATACCCAGCATAGCAGTATTCAGAATAATCC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| pold1ta53c/ta53c | Homozygous | ♀+/- ♂+/- | 4 figures from 3 publications | Fig. 1 from Plaster et al., 2006 |
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Supplemental Information
- Genotyping protocol
- None
- Plaster, N., Sonntag, C., Busse, C.E., and Hammerschmidt, M. (2006) p53 deficiency rescues apoptosis and differentiation of multiple cell types in zebrafish flathead mutants deficient for zygotic DNA polymerase delta1. Cell death and differentiation. 13(2):223-235
- Tsujikawa, M., and Malicki, J. (2004) Genetics of photoreceptor development and function in zebrafish. The International journal of developmental biology. 48(8-9):925-934
- Malicki, J. (2000) Harnessing the power of forward genetics – analysis of neuronal diversity and patterning in the zebrafish retina. Trends in neurosciences. 23(11):531-541
- Neuhauss, S.C.F., Biehlmaier, O., Seeliger, M.W., Das, T., Kohler, K., Harris, W.A., and Baier, H. (1999) Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19(19):8603-8615
- Furutani-Seiki, M., Jiang, Y.J., Brand, M., Heisenberg, C.P., Houart, C., Beuchle, D., van Eeden, F.J.M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Neural degeneration mutants in the zebrafish, Danio rerio. Development (Cambridge, England). 123:229-239
- Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
- Heisenberg, C.P., Brand, M., Jiang, Y.J., Warga, R.M., Beuchle, D., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Genes involved in forebrain development in the zebrafish, Danio rerio. Development (Cambridge, England). 123:191-203
- Schilling, T.F., Piotrowski, T., Grandel, H., Brand, M., Heisenberg, C.P., Jiang, Y.J., Beuchle, D., Hammerschmidt, M., Kane, D.A., Mullins, M.C., van Eeden, F.J., Kelsh, R.N., Furutani-Seiki, M., Granato, M., Haffter, P., Odenthal, J., Warga, R.M., Trowe, T., and Nüsslein-Volhard, C. (1996) Jaw and branchial arch mutants in zebrafish. I. Branchial arches. Development (Cambridge, England). 123:329-344
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