Genomic Feature
tw25e
- ID
- ZDB-ALT-980203-1459
- Name
- tw25e
- Synonyms
-
- tw25
- W25E (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 7: 26854440 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- None
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
CCCTGTTACTTGGCTGATCTTTTGCTTTGGGTGGAAAAGGTGAGTTTTTGTGTAGTAGAAAGCCCTGAAATGATGAACACTTATCTGGAGCTGTAGGGAATTTCCTGGGCTCATCCAGCTGTGCTCCATTTGGAGTGCAGCCTCATCAGAACCAGCTGCCCGTATGCGCATATGTGTGGGGTGAGATAAAAAGACAGTGTATGTTGCATGGCCATATTTGCAGCTCTCCCAATACTCGCTTCGTTCCCTCAAACCGAGCGTCGTTTGAAGTTTTATAGACTCGTTGTAGAACCAGGACGCAAAAGCAACTCTGTTAAATGCTCCGGAGTGGCATGTTCGCACATTAGTCATGTAAAACCAGATTGGGGATGTGTTTTATCTTCAGTGCCTTTTGCAGATGCTTGCGCTGACAGCGTTGTCATCTACATTGGGTTGTTTTTTTCCCACAGAGCCCTGCTGGCTGGGGGAGGCTTCTCCACATGGACCTACAGACAAGGTTA
T/A GATGTCAGCATACCTGTGTATAGCCCTTTATCTGCTGAGGTGGACCTTCCTGAGAGGCAACCCGGGTGAGATCCTGCTCATTGACGCTGGCCAATTGTTTTTTATGTAAAAATGCAAAATGGCATCTCATAAAATGTTTTTCTTCCAGTCCTCGGCGCTACTTCATTCTGTCATCTCAGACAGCCATTCATAGGGAATACCGTGTGGAACTGGAAAGGCTGAAGGATGAGAATGGGGAGGCCCTGCTTCTGTTAGACAAATGCAGTAATCTCTCTCAGGGTTTGACCTCGGTTAGAAAGCGCTGCTATAAAGGACAGGTGTACGACTACCCACAAATTTTACAGGTTGGTGTGTCTCAACATTCAGCTTACATGTAAATCAAATCAAGTCAAATCACTTTTATTGTCACATCATCAGCAGCACGTGTGCTATGTTGAGTGAAAAGCTTAGGTGCTGGCTCCAGACAGTGCAACTACAACGGCAATGCAAAATACAGACAG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| ext2tw25e/tw25e | Homozygous | ♀+/- ♂+/- | 20 figures  from 9 publications | 11 figures from 6 publications | |
| ext2tw25e/tw25e; y1Tg | Complex | 5 figures from Holmborn et al., 2012 | 2 figures from Holmborn et al., 2012 | ||
| ext2tw25e/tw25e; uxs1hi954Tg/hi954Tg; y1Tg | Complex | 3 figures from Holmborn et al., 2012 | Fig. 10 from Holmborn et al., 2012 |
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Supplemental Information
- Genotyping protocol
- None
- Jones, A.A., Diamantopoulou, E., Baxendale, S., Whitfield, T.T. (2022) Presence of chondroitin sulphate and requirement for heparan sulphate biosynthesis in the developing zebrafish inner ear. Frontiers in cell and developmental biology. 10:959624
- Holmborn, K., Habicher, J., Kasza, Z., Eriksson, A.S., Filipek-Gorniok, B., Gopal, S., Couchman, J.R., Ahlberg, P., Wiweger, M., Spillman, D., Kreuger, J., and Ledin, J. (2012) On the roles and regulation of chondroitin sulfate and heparan sulfate in zebrafish pharyngeal cartilage morphogenesis. The Journal of biological chemistry. 287(40):33905-33916
- Fischer, S., Filipek-Gorniok, B., and Ledin, J. (2011) Zebrafish Ext2 is necessary for Fgf and Wnt signaling, but not for Hh signaling. BMC Developmental Biology. 11(1):53
- Norton, W.H., Ledin, J., Grandel, H., and Neumann, C.J. (2005) HSPG synthesis by zebrafish Ext2 and Extl3 is required for Fgf10 signalling during limb development. Development (Cambridge, England). 132(22):4963-4973
- Kawakami, Y., Esteban, C.R., Matsui, T., Rodriguez-Leon, J., Kato, S., and Izpisúa Belmonte, J.C. (2004) Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos. Development (Cambridge, England). 131(19):4763-4774
- Lee, J.S., von der Hardt, S., Rusch, M.A., Stringer, S.E., Stickney, H.L., Talbot, W.S., Geisler, R., Nüsslein-Volhard, C., Selleck, S.B., Chien, C.B., and Roehl, H. (2004) Axon Sorting in the Optic Tract Requires HSPG Synthesis by ext2 (dackel) and extl3 (boxer). Neuron. 44(6):947-960
- Begemann, G. and Ingham, P.W. (2000) Developmental regulation of Tbx5 in zebrafish embryogenesis. Mechanisms of Development. 90(2):299-304
- Grandel, H., Draper, B.W., and Schulte-Merker, S. (2000) dackel acts in the ectoderm of the zebrafish pectoral fin bud to maintain AER signaling. Development (Cambridge, England). 127(19):4169-4178
- Neuhauss, S.C.F., Biehlmaier, O., Seeliger, M.W., Das, T., Kohler, K., Harris, W.A., and Baier, H. (1999) Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19(19):8603-8615
- Karlstrom, R.O., Trowe, T., and Bonhoeffer, F. (1997) Genetic analysis of axon guidance and mapping in the zebrafish. Trends in neurosciences. 20(1):3-8
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