Genomic Feature
tw11
- ID
- ZDB-ALT-980203-1454
- Name
- tw11
- Synonyms
-
- W11A (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
Comment | Citation |
---|---|
An A1126T substitution results in a stop codon (K376Stop) truncating the ... | Dutton et al., 2001 |
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 3: 1499549 (GRCz11) (1) Details
- Nucleotide change
- A/T
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- A>T at position 1126 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Lys>Stop at position 376 (1)
- Flanking Sequence
-
CTATTTTTGAGTAAACAACAACTACTTTTGAAAAACGAAAAACCAACTAAAACTATTTTCTTGTATTTGTTTGCTCAGGTCAGAGTCACAGCCCTCCAACGCCCCCTACCACCCCCAAGACGGAACTGCAGGGAGGAAAATCAGGCGAGGGCAAGCGTGAGGGCGGAGCCTCTCGGAGTGGACTGGGGGTGGGAGCAGATGGAAGCTCCGCCTCATCGTCTGCCAGCGGGAAACCGCACATCGACTTCGGTAACGTGGACATTGGCGAAATCAGCCATGACGTGATGGCCAACATGGAGCCGTTCGACGTGAACGAGTTCGACCAGTATCTCCCACCCAATGGCCACCCGCAGGCGTCCGCCACTGCCAGCGCAGGATCTGCAGCGCCATCGTATACATACGGCATCTCCAGCGCGCTAGCGGCCGCTAGTGGCCACTCCACCGCATGGCTGTCCAAGCAGCAACTGCCGTCCCAGCAGCATTTGGGCGCAGATGGCGGG
A/T AAACGCAGATAAAGAGTGAAACACACTTCCCTGGGGATACAGCGGCGAGCGGTTCACACGTCACATACACGCCGCTAACACTGCCGCACTACAGCTCCGCCTTCCCCTCGCTGGCGTCCCGCGCACAATTCGCCGAATACGCCGAGCACCAGGCCTCGGGATCCTACTACGCCCACTCCAGCCAGACCTCAGGCCTCTACTCCGCCTTCTCCTACATGGGCCCCTCACAGCGGCCCCTGTACACCGCCATTCCGGATCCGGGATCCGTGCCGCAGTCACACAGCCCTACGCATTGGGAGCAGCCCGTATACACCACACTGTCTCGACCGTGACACACTCTACCAAGATGACCAGTCACTAAAGGTCCAACCGTAAGGTGTGTGTGTGTGTGTGCTAAAAATCATCGAAACACTCGCCTGCACCACAATCGACACAAACTGAGATCTGAGAAAAGAGTGTGTGTGTGTGTGGAGATCTGCAGGGAAATATTCTCACGTGCC - Additional Sequence
- None
Fish
Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
---|---|---|---|---|---|
sox10tw11/tw11 | Homozygous | ♀+/- ♂+/- | 11 figures ![]() | 6 figures ![]() | |
sox10tw11/tw11 (AB) | Homozygous | ♀+/- ♂+/- | Fig. 4 ![]() | ||
sox10tw11/tw11; vu17Tg (AB) | Complex | Fig. 8 from Kucenas et al., 2008 |
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Supplemental Information
- Genotyping protocol
- None
- Lewis, G.M., Kucenas, S. (2014) Perineurial Glia Are Essential for Motor Axon Regrowth following Nerve Injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34:12762-77
- Dooley, C.M., Mongera, A., Walderich, B., and Nüsslein-Volhard, C. (2013) On the embryonic origin of adult melanophores: the role of ErbB and Kit signalling in establishing melanophore stem cells in zebrafish. Development (Cambridge, England). 140(5):1003-1013
- Takada, N., and Appel, B. (2011) swap70 Promotes neural precursor cell cycle exit and oligodendrocyte formation. Molecular and cellular neurosciences. 48(3):225-35
- Takada, N., Kucenas, S., and Appel, B. (2010) Sox10 is necessary for oligodendrocyte survival following axon wrapping. Glia. 58(8):996-1006
- Rojas-Muñoz, A., Rajadhyksha, S., Gilmour, D., van Bebber, F., Antos, C., Rodríguez Esteban, C., Nüsslein-Volhard, C., and Izpisúa Belmonte, J.C. (2009) ErbB2 and ErbB3 regulate amputation-induced proliferation and migration during vertebrate regeneration. Developmental Biology. 327(1):177-190
- Kucenas, S., Takada, N., Park, H.C., Woodruff, E., Broadie, K., and Appel, B. (2008) CNS-derived glia ensheath peripheral nerves and mediate motor root development. Nature Neuroscience. 11(2):143-151
- Pezeron, G., Anselme, I., Laplante, M., Ellingsen, S., Becker, T.S., Rosa, F.M., Charnay, P., Schneider-Maunoury, S., Mourrain, P., and Ghislain, J. (2006) Duplicate sfrp1 genes in zebrafish: sfrp1a is dynamically expressed in the developing central nervous system, gut and lateral line. Gene expression patterns : GEP. 6(8):835-842
- Elworthy, S., Pinto, J.P., Pettifer, A., Cancela, M.L., and Kelsh, R.N. (2005) Phox2b function in the enteric nervous system is conserved in zebrafish and is sox10-dependent. Mechanisms of Development. 122(5):659-669
- Grant, K.A., Raible, D.W., and Piotrowski, T. (2005) Regulation of latent sensory hair cell precursors by glia in the zebrafish lateral line. Neuron. 45(1):69-80
- Dutton, K.A., Pauliny, A., Lopes, S.S., Elworthy, S., Carney, T.J., Rauch, J., Geisler, R., Haffter, P., and Kelsh, R.N. (2001) Zebrafish colourless encodes sox10 and specifies non-ectomesenchymal neural crest fates. Development (Cambridge, England). 128(21):4113-4125
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