Genomic Feature
tm208
- ID
- ZDB-ALT-980203-1362
- Name
- tm208
- Synonyms
-
- AM008A (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
-
Zebrafish International Resource Center (ZIRC)
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European Zebrafish Resource Center (EZRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 5: 15209458 (GRCz11) (1) Details
- Nucleotide change
- A/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- A>T at position 877 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Arg>Stop at position 293 (1)
- Flanking Sequence
-
CTCTTGATCTCCAACTCTCACCGCGGGCTTTACATTTGTTTTTCAACTCATTCCGGAAAATCACGCACACATCTTCATCCAGCGCTTTTCCACAGCCATGAGGCATTACCTCGCGCGTCCGTACTTAACATAAATACTTTACAATCCGTGTCCAAATAAATGTTGAAATGTTTTATAGTTAAGATAAATACAATCGTCGAGTGTCTACGCCCTGGAACACCGCACATATTGCATTAAAGTTGTTGTATAAGCGATTAATTGGAGCGTTACATGGTTTAATGAGTTTACAATTTAAAAAGGCTTATAATAACACAAGGCTCTGGAATGAACTTGATTACCTGTATAAACAATAACACTGAGTGAGCAAAAATAAATGAACAATACTGGAGGTGAATACCCGTATTTGTTCATTTGGCAATTCCATATTTTTCAACTTCTCTCTTTATTTCTCTCAGATAACACAACTGAAAATCGCCAGCAATCCGTTTGCCAAAGGCTTC
A/T GAGACTGTGATCCCGAGGACTGGTGAGTTTTACCATATTATTTTCATCCATTTATCTGAGGTAAAACATAAGTAGTTAGGCAGAAATTGATTTCAATAAAACAAAAATGCACTTTAGACAATGAATGCTTACTAGATTTGTATAGCATAACTGTGCTTTGTTTTGTAGCTACAGGCCTACTTGACCGTTTTCCTTTGTACCTTAAATATTTTCATTATTATTATTATTATTATTATTATTATTATTATTATTATTATTATTATTATTATTATAACTTATGTTTAATTAAATAGGAAAATATTGAATCATGCTCACATGTTTTAATCTATTAAGGCCTTATATTACAGATAAAATATTGTTCTCAACTCTGAAGCTAAAACTGGTATCTTTAAAAACACATATTGGGTCAAACATGGACAATACCAAAGTTGTATATTATATATATATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| tbx1tm208/tm208 | Homozygous | ♀+/- ♂+/- | 25 figures  from 7 publications | 21 figures from 8 publications | |
| tbx1tm208/+ | Heterozygous | ♀+/- ♂+/- | Fig. 5 from Radosevic et al., 2011 | ||
| tbx1tm208/+ (AB) | Heterozygous | Unknown | |||
| tbx1tm208/tm208; twu34Tg | Complex | Fig. S2 from Choudhry et al., 2013 | |||
| tbx1tm208/tm208; twu34Tg (AB) | Complex | ||||
| tbx1tm208/+; wnt11fh224/+ | Complex | Fig. 6 from Choudhry et al., 2013 |
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Supplemental Information
- Genotyping protocol
- tm208.pdf
- Jones, A.A., Diamantopoulou, E., Baxendale, S., Whitfield, T.T. (2022) Presence of chondroitin sulphate and requirement for heparan sulphate biosynthesis in the developing zebrafish inner ear. Frontiers in cell and developmental biology. 10:959624
- Alexander, C., Piloto, S., Le Pabic, P., Schilling, T.F. (2014) Wnt signaling interacts with bmp and edn1 to regulate dorsal-ventral patterning and growth of the craniofacial skeleton. PLoS Genetics. 10:e1004479
- Maier, E.C., Whitfield, T.T. (2014) RA and FGF Signalling Are Required in the Zebrafish Otic Vesicle to Pattern and Maintain Ventral Otic Identities. PLoS Genetics. 10:e1004858
- Choudhry, P., and Trede, N.S. (2013) DiGeorge Syndrome Gene tbx1 Functions through wnt11r to Regulate Heart Looping and Differentiation. PLoS One. 8(3):e58145
- Hill, J.T., Demarest, B.L., Bisgrove, B.W., Gorsi, B., Su, Y.C., and Yost, H.J. (2013) MMAPPR: Mutation Mapping Analysis Pipeline for Pooled RNA-seq. Genome research. 23(4):687-697
- Nevis, K., Obregon, P., Walsh, C., Guner-Ataman, B., Burns, C.G., and Burns, C.E. (2013) Tbx1 is required for second heart field proliferation in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 242(5):540-549
- Radosevic, M., Robert-Moreno, A., Coolen, M., Bally-Cuif, L., and Alsina, B. (2011) Her9 represses neurogenic fate downstream of Tbx1 and retinoic acid signaling in the inner ear. Development (Cambridge, England). 138(3):397-408
- Knight, R.D., Mebus, K., and Roehl, H.H. (2008) Mandibular arch muscle identity is regulated by a conserved molecular process during vertebrate development. Journal of experimental zoology. Part B, Molecular and developmental evolution. 310(4):355-369
- Holzschuh, J., Wada, N., Wada, C., Schaffer, A., Javidan, Y., Tallafuss, A., Bally-Cuif, L., and Schilling, T.F. (2005) Requirements for endoderm and BMP signaling in sensory neurogenesis in zebrafish. Development (Cambridge, England). 132(16):3731-3742
- Piotrowski, T., Ahn, D.-G., Schilling, T.F., Nair, S., Ruvinsky, I., Geisler, R., Rauch, G.-J., Haffter, P., Zon, L.I., Zhou, Y., Foott, H., Dawid, I.B., and Ho, R.K. (2003) The zebrafish van gogh mutation disrupts tbx1, which is involved in the DiGeorge deletion syndrome in humans. Development (Cambridge, England). 130(20):5043-5052
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