Genomic Feature
ty68b
- ID
- ZDB-ALT-980203-1295
- Name
- ty68b
- Synonyms
-
- Y068B (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 12: 13728721 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- None
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Lys>Asn at position 97 (1)
- Flanking Sequence
-
GCAGATTACGCGCCCAGGGTAGATTTAGATGCGCAAAATGCATTAAACTCACCCCACATATAAATAGTCCTGTACATAATTTAAAACATTTTTGGATGTAACTGCGGAAAGCCTCAACATTTCAATTAATGATATTGCAATTGCGACCTTACACTTTAAATTGAGAGTGAATGCGTGGGTTTGACAGTTTCCTAATGAAGATGTTTCAGCTAAAACCCTTAAACTTTTAAAACCCGCAAACAAATACAGGGGTTTGTTGGGGTAGAGCCACGCATCATATTTCAGTACAAACTTTCACATTTAATTCACTGTGATGCTTGCTGTTTCTTTGCAATTACATATTAAATTTACTGAGGTTTCTACATTATTACTAATTGCGCATTTTGACTAAAAAAAGTTTAAGTTTTTCAATTACTTAACCCTACCTCTGATAAAGTAAGCTTCTTCTCTGGCGAGTTCTGGATGACCATTGCGATCATTGCCAGGTAAGAGTACGGTGG
T/A TTGGGATAACGCTGATAGTTTTTCTTCTTTCCTCCACTGGAGTTTCCATCCTGCAGTTCCCATGGGCCTTGATTCGTCGCTTTGGCTCTATAACAAGAGTCCTGCGCCATCCCTGTGGACTTATCCAGCCGGCCACCGAGCTCCAGCAAAGGGTTTGAGGAGCGATGACAGCTGCGCTTGGAAGAGGAATAGCCGATTCTGCAGTCAAGGTGATGGTCGCGTTGTGCTCCTTCTCCTACGGTGATCACGGGTGGTGCCAACAAGCCTGGACCCCCCCAGTGCTTTGTCATGCTGATGTAGTGGGGGGAGGTGGAAGGTATGGTCGCTCCTCAACCCCTCAGACTGCTGGCTCCAGGTCAACTCTATTTGAGCAGCAAACAATTCACAGTTTCATGTCAATCCCGCTGCGTAATGGGAGTGAGAATGAGGCGCGATGCGCGATCACCGCGGGGGAGGACACTATACATCAGCGATCAGATTTACTGTGAAAGGCAGTTTAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| foxh1ty68b/ty68b | Homozygous | ♀+/- ♂+/- | 10 figures  from 3 publications | 3 figures from 3 publications | |
| foxh1ty68b/ty68b | Homozygous | ♀-/- ♂+/- | |||
| foxh1ty68b/ty68b | Homozygous | ♀-/- ♂-/- |
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Supplemental Information
- Genotyping protocol
- None
- Choi, J., Dong, L., Ahn, J., Dao, D., Hammerschmidt, M., and Chen, J.N. (2007) FoxH1 negatively modulates flk1 gene expression and vascular formation in zebrafish. Developmental Biology. 304(2):735-744
- Pei, W., Noushmehr, H., Costa, J., Ouspenskaia, M.V., Elkahloun, A.G., and Feldman, B. (2007) An early requirement for maternal FoxH1 during zebrafish gastrulation. Developmental Biology. 310(1):10-22
- Bisgrove, B.W., Snarr, B.S., Emrazian, A., and Yost, H.J. (2005) Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis. Developmental Biology. 287(2):274-288
- Essner, J.J., Amack, J.D., Nyholm, M.K., Harris, E.B., and Yost, H.J. (2005) Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut. Development (Cambridge, England). 132(6):1247-1260
- Mathieu, J., Barth, A., Rosa, F.M., Wilson, S.W., and Peyriéras, N. (2002) Distinct and cooperative roles for Nodal and Hedgehog signals during hypothalamic development. Development (Cambridge, England). 129(13):3055-3065
- Bisgrove, B.W., Essner, J.J., Yost, H.J. (2000) Multiple pathways in the midline regulate concordant brain, heart and gut left-right asymmetry. Development (Cambridge, England). 127(16):3567-3579
- Essner, J.J., Branford, W.W., Zhang, J., and Yost, H.J. (2000) Mesendoderm and left-right brain, heart and gut development are differentially regulated by pitx2 isoforms. Development (Cambridge, England). 127(5):1081-1093
- Odenthal, J., van Eeden, F.J., Haffter, P., Ingham, P.W., and Nüsslein-Volhard, C. (2000) Two distinct cell populations in the floor plate of the zebrafish are induced by different pathways. Developmental Biology. 219(2):350-363
- Pogoda, H.M., Solnica-Krezel, L., Driever, W., and Meyer, D. (2000) The zebrafish forkhead transcription factor FoxH1/Fast1 is a modulator of Nodal signaling required for organizer formation. Current biology : CB. 10(17):1041-1049
- Neuhauss, S.C.F., Biehlmaier, O., Seeliger, M.W., Das, T., Kohler, K., Harris, W.A., and Baier, H. (1999) Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19(19):8603-8615
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