Genomic Feature
tt261
- ID
- ZDB-ALT-980203-1232
- Name
- tt261
- Synonyms
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
-
Zebrafish International Resource Center (ZIRC)
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European Zebrafish Resource Center (EZRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 2: 9061942 (GRCz11) (1) Details
- Nucleotide change
- T/C
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>C (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Met>Thr at position 1 (1)
- Flanking Sequence
-
GGGAAAACAGGAGCACCCGTAGGAAACCCACGCGAATGGAGGGAGAACATGCAAACTCCACACAGAAATGCCAACTGACCCAGCTGAGGCTCGAACCAGCGACCTTTTTGCTGTCAGACGACAGCACTACCTACTGCGCCACTGCATCGCCCATAATAATAATAATAATAATAATAATAATAATAATAATAATAATAATAATAATAATAATAATAATAATAATAATAATAATCAGTAAATAAACACTACAAAATGATTTCTGGAGTTTATATATATATATATATATATATATATATATATATATATATATATATATATATGCAATAAACATTAATTTTACATTAATTTAATTATTTTGTTCATTACTGACTTTTTAAAATATTTGAATAGAGACAAACCTTTTACATTGAAGTTAGGACTTTTACTCAAACCGGAAGTTTAGCGCTTCCTGGTTGTCATTGCAAATCTACACTGTCACTTGTACCGGTGACGAACGATAA
T/C GGATTATTCCAATTTATTTACAGTGTATTCATGCCTTCTTCTGTTTGTTTCCATACCATGCGCATACAGCAATTATGTTGAGGTGAGTGTCTTTATTCACAGCTGTTAGAAGAGCTGATATAAACACACTGAGTGCGTGAGCGCGAGCAGTGAAGCTATCGACACTAATATTCAACCTCTGCATAAATGTTTCTTTTATAATAATATATTATTTTATTTTGATTGTTGATTCGGATTTAATTCAAATATACACTGACCTTAGATAGTTAGATCGTAGCTAGTTTACAATACATTGCTATTATGTCGTCTAGATTGTTATTAACACCATGTCTTGGCATAATAGACATCAATTATTTACAAAAATTGTTTAGATGGTAACCAAGCACTTTTTGTTACATAACACATGCAATATTTTCGCTATTTTGTCTCAATAACGTTGTGCATTTTAAATATTCAAAGTGTATATTTTCAAAAGCTTGCTTTGTTATAGTGTACAGTAT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| pigktt261/tt261 | Homozygous | ♀+/- ♂+/- | 8 figures  from 5 publications | Fig. 2 from Carmean et al., 2015 | |
| pigktt261/+ (AB) | Heterozygous | Unknown | |||
| pigktt261/tt261; rw011aTg | Complex | Fig. 5 from Sadamitsu et al., 2024 |
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Supplemental Information
- Genotyping protocol
- None
- Sadamitsu, K., Yanagi, K., Hasegawa, Y., Murakami, Y., Low, S.E., Ooshima, D., Matsubara, Y., Okamoto, N., Kaname, T., Hirata, H. (2024) A novel homozygous variant of the PIGK gene caused by paternal disomy in a patient with neurodevelopmental disorder, cerebellar atrophy, and seizures. Journal of Human Genetics. 69(11):553-563
- Mora-Zamorano, F.X., Svoboda, K.R., Carvan, M.J. (2016) The Nicotine-Evoked Locomotor Response: A Behavioral Paradigm for Toxicity Screening in Zebrafish (Danio rerio) Embryos and Eleutheroembryos Exposed to Methylmercury. PLoS One. 11:e0154570
- Carmean, V., Yonkers, M.A., Tellez, M.B., Willer, J.R., Willer, G.B., Gregg, R.G., Geisler, R., Neuhauss, S.C., Ribera, A.B. (2015) pigk mutation underlies macho behavior and affects Rohon-Beard cell excitability. Journal of neurophysiology. 114(2):1146-57
- Easley-Neal, C., Fierro, J., Buchanan, J., and Washbourne, P. (2013) Late Recruitment of Synapsin to Nascent Synapses Is Regulated by Cdk5. Cell Reports. 3(4):1199-1212
- Poulain, F.E., and Chien, C.B. (2013) Proteoglycan-mediated axon degeneration corrects pretarget topographic sorting errors. Neuron. 78(1):49-56
- Wright, M.A., and Ribera, A.B. (2010) Brain-derived neurotrophic factor mediates non-cell-autonomous regulation of sensory neuron position and identity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(43):14513-14521
- Pineda, R.H., Heiser, R.A., and Ribera, A.B. (2005) Developmental, molecular and genetic dissection of INa in vivo in embryonic zebrafish sensory neurons. Journal of neurophysiology. 93(6):3582-3593
- Neuhauss, S.C. (2003) Behavioral genetic approaches to visual system development and function in zebrafish. Journal of neurobiology. 54(1):148-160
- Gnuegge, L., Schmid, S., and Neuhauss, S.C.F. (2001) Analysis of the activity-deprived zebrafish mutant macho reveals an essential requirement of neuronal activity for the development of a fine-grained visuotopic map. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21(10):3542-3548
- Svoboda, K.R., Linares, A.E., and Ribera, A.B. (2001) Activity regulates programmed cell death of zebrafish Rohon-Beard neurons. Development (Cambridge, England). 128(18):3511-3520
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