Genomic Feature
tf18b
- ID
- ZDB-ALT-980203-1127
- Name
- tf18b
- Synonyms
-
- F18B (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 20: 51508415 (GRCz11) (1) Details
- Nucleotide change
- A/T
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Tyr>Stop at position 164 (1)
- Flanking Sequence
-
TTCCAGGCATATATGTGGATGGGTTTTCCATCTTTACTTAGCCCACACGGAATCTCCGCGCGCAGAATTCCACAGAATTCTGCAGATGTTTAGCTCATTATCAATTCTGTTTATTTACTTCAGTAAATGTGTAAATCTGAATTTATTCAGTTTTTATTCAGTAATTTATTACTTTTTATTTAATATATTAAGGTTTTAGTTATGATACTCCGCTGGATACTCACAAAATAATTCCGCAAAAATCCGCAGATTTTTACCAAAATTCTTAGTAGAAATAGCAAAAAAACGCCCGCAGATTCCGTCTGGCCCTGCTTATAATCTGCATCTTAAAACTGAGTCAACATCCTTCAAAGGCTCCAGCAAACGCTGGTTCTACTCACCTGCAGTGGGTTTGAGAAGTCAGGCAGATCAGGAACGAGGATCCCGACCAGAGCACAAACCACAATGAGGACAGTGCAAATCCCCAACACCACCACCGGCCAATCAGCAATCAGCTCTGC
A/T TAACTGCCAATGACATCAGAACATACATCATTTGTATACACAAGTCCTTTTATACTACAGAGCTGTCCCGTTCTATTCAATTGAAGTTTATTTGTATAGTGCTTTTCACAATAATTATGGGTAATACCGTATACAGTGCTTGATTCTGATTGGCTGATAAGGACACTAAAGTGTGCTGTTGTTTTCAGATATGATTTGAGGCCTGAAATATAACATATATGCAGTGCTCAGTATAACAGAGTGCATGCCCTTTTAATGGATCTTAATCCATAATATTTCAATCCATTTCTCAGTAAATATAAACAATTTATTTTGGTGCATTAAAATAAGAGTTTAGTCACTGAACATCTTAGGAAATAGAAAGATGTTACATTCAAACAACTGCAACAGTTTGACTAAGGGTGCTTTCACACCTGCCTTGTTTAGTTCGATTGAATCACACTAGAGTTCGTTTCCCCTTTTGGTGCGGTTCCTATGGGCAGGTGAGAATGCAGCAATCG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| disp1tf18b/tf18b | Homozygous | ♀+/- ♂+/- | 15 figures  from 9 publications | text only from Nakano et al., 2004 | |
| disp1tf18b/tf18b; i233Tg | Complex | Fig. 3 from Maurya et al., 2011 | Fig. 3 from Maurya et al., 2011 | ||
| disp1tf18b/tf18b; i233Tg + MO2-bmpr1ba | Complex | Fig. 3 from Maurya et al., 2011 |
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Supplemental Information
- Genotyping protocol
- None
- Maurya, A.K., Tan, H., Souren, M., Wang, X., Wittbrodt, J., and Ingham, P.W. (2011) Integration of Hedgehog and BMP signalling by the engrailed2a gene in the zebrafish myotome. Development (Cambridge, England). 138(4):755-765
- Nakano, Y., Kim, H.R., Kawakami, A., Roy, S., Schier, A.F., and Ingham, P.W. (2004) Inactivation of dispatched 1 by the chameleon mutation disrupts Hedgehog signalling in the zebrafish embryo. Developmental Biology. 269(2):381-392
- Hammond, K.L., Loynes, H.E., Folarin, A.A., Smith, J., and Whitfield, T.T. (2003) Hedgehog signalling is required for correct anteroposterior patterning of the zebrafish otic vesicle. Development (Cambridge, England). 130(7):1403-1417
- Malicki, J. (2000) Harnessing the power of forward genetics – analysis of neuronal diversity and patterning in the zebrafish retina. Trends in neurosciences. 23(11):531-541
- Karlstrom, R.O., Trowe, T., and Bonhoeffer, F. (1997) Genetic analysis of axon guidance and mapping in the zebrafish. Trends in neurosciences. 20(1):3-8
- Brand, M., Heisenberg, C.P., Warga, R.M., Pelegri, F., Karlstrom, R.O., Beuchle, D., Picker, A., Jiang, Y.J., Furutani-Seiki, M., van Eeden, F.J., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Mutations affecting development of the midline and general body shape during zebrafish embryogenesis. Development (Cambridge, England). 123:129-142
- Chen, J.N., Haffter, P., Odenthal, J., Vogelsang, E., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., and Nüsslein-Volhard, C. (1996) Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development (Cambridge, England). 123:293-302
- Granato, M., van Eeden, F.J., Schach, U., Trowe, T., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. Development (Cambridge, England). 123:399-413
- Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
- Karlstrom, R.O., Trowe, T., Klostermann, S., Baier, H., Brand, M., Crawford, A.D., Grunewald, B., Haffter, P., Hoffman, H., Meyer, S.U., Muller, B.K., Richter, S., van Eeden, F.J., Nüsslein-Volhard, C., and Bonhoeffer, F. (1996) Zebrafish mutations affecting retinotectal axon pathfinding. Development (Cambridge, England). 123:427-438
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