Genomic Feature
ty86d
- ID
- ZDB-ALT-980203-1093
- Name
- ty86d
- Synonyms
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
-
Zebrafish International Resource Center (ZIRC)
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European Zebrafish Resource Center (EZRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 20: 9237311 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Phe>Tyr at position 241 (1)
- Flanking Sequence
-
TGCTTTTCTGAGTGCTTGTCATGCTTATTATACTTACTGTTTTCTATACAAACTATGACATTCTATTTATGTACATGAAAATGTATAGTTGACTGAACTGTCATCAAATTTAAAAGTCATTTAGAGGTCAGAAAACCTCTGCCTGCTTTTGGACCCCTGTGGAAAAGAGTTATAGTTTTAAAATACGAGTTTGATTGTCCTCTGTTAACCTGAGAGTGCAAATCTTGGGTTGCAGTCGGCTCACACGTGAATCTACTTGCAAGTGCTTGATGCATTGCTTCCTGCAATTGTGACTCTGTAAACATATGCAGCTTAAAAACAGCCTCCACGTGGTGTAAAAATAGTGCTAGATAGGCAAATCAAACTGGTTAGTCCCGTTTTGAATAAAGATAAATCACTTTGTTTCCATACAGGGGTGGACCCATCCGTAAACTACCCCACTCTCTACAGATTCTTTGTCCAGCTATGGATCTACCTGGGCCTTGCTTGGTTGTCATTGT
T/A CTTCAGTTGGAACGTGCATATGGTGGTGGAAGCTCATAAAGTTTTAAAGAAAAGGAGGATGAGACGCCACAGGCTGCCCACCGATGACGTGCCGGAAAAAAAAGAAGTGAAAAAAACACCAAAGCCACCTCCTCGCTCTGGAGTCATTGACATCTTTGAGTTCATGTCCGAGAAGGTCGAGGACTACAGCGACGTTATCCGAGCTATCGGAGCAGACGAAAAGAGAAGGAAAAAGAAACAGGAGGAGGAACTGGCACGATCCAAGAGCTGCAGTGACCTTTTGCAAGGCCTGGTCATCCCGCTTGATCACTCTCCTCGTCTGCAACGGCGGTTCAGTGTCAGCGCCAACATGTGCATGGCCATATCTGATGAGTCTGTGGATGGCCTCAACAATAACAATTGCAAACAAGAGGATGACACACTAACTAAAGTGCGCCATAAAGACCAGAAGGTTAATCGAGAGAGAGCGGAGAATCCTGCACGTTGTGCATGGGACTCTA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| kcnk5bty86d/ty86d | Homozygous | Unknown | 3 figures  from 2 publications | Fig. 5 from König et al., 2017 | |
| kcnk5bty86d/ty86d | Homozygous | ♀+/- ♂+/- | Fig. 11 from Bhadra et al., 2015 | 4 figures from 2 publications | |
| kcnk5bty86d/ty86d (C32) | Homozygous | ♀+/- ♂+/- | 2 figures from Ton et al., 2013 | ||
| kcnk5bty86d/+ | Heterozygous | Unknown | 5 figures from 3 publications | Fig. 5 from Sims Jr et al., 2009 | |
| kcnk5bty86d/+ | Heterozygous | ♀+/- ♂+/- | 4 figures from van Eeden et al., 1996 | ||
| kcnk5bty86d/+ (AB) | Heterozygous | Unknown | |||
| kcnk5bty86d/+ (AB) | Heterozygous | ♀+/- ♂+/- | Fig. S2 from Daane et al., 2021 | ||
| kcnk5bty86d (AB/TU) | Unknown | Unknown | text only from Cooper et al., 2015 | ||
| kcnk5bty86d/+ + MO2-gja1b | Complex | Fig. 5 from Sims Jr et al., 2009 | |||
| kcnk5bty86d/ty86d + MO2-gja1b (C32) | Complex | Fig. 9 from Ton et al., 2013 |
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Supplemental Information
- Genotyping protocol
- None
- Daane, J.M., Blum, N., Lanni, J., Boldt, H., Iovine, M.K., Higdon, C.W., Johnson, S.L., Lovejoy, N.R., Harris, M.P. (2021) Modulation of bioelectric cues in the evolution of flying fishes. Current biology : CB. 31(22):5052-5061.e8
- König, D., Dagenais, P., Senk, A., Djonov, V., Aegerter, C.M., Jaźwińska, A. (2019) Distribution and Restoration of Serotonin-Immunoreactive Paraneuronal Cells During Caudal Fin Regeneration in Zebrafish. Frontiers in molecular neuroscience. 12:227
- Murciano, C., Cazorla-Vázquez, S., Gutiérrez, J., Hijano, J.A., Ruiz-Sánchez, J., Mesa-Almagro, L., Martín-Reyes, F., Fernández, T.D., Marí-Beffa, M. (2018) Widening control of fin inter-rays in zebrafish and inferences about actinopterygian fins. Journal of anatomy. 232(5):783-805
- Dardis, G., Tryon, R., Ton, Q., Johnson, S.L., Iovine, M.K. (2017) Cx43 suppresses evx1 expression to regulate joint initiation in the regenerating fin. Developmental Dynamics : an official publication of the American Association of Anatomists. 246(9):691-699
- König, D., Page, L., Chassot, B., Jaźwińska, A. (2017) Dynamics of actinotrichia regeneration in the adult zebrafish fin. Developmental Biology. 433(2):416-432
- Bhadra, J., Iovine, M.K. (2015) Hsp47 mediates Cx43-dependent skeletal growth and patterning in the regenerating fin. Mechanisms of Development. 138 Pt 3:364-74
- Cooper, T.K., Murray, K.N., Spagnoli, S., Spitsbergen, J.M. (2015) Primary Intestinal and Vertebral Chordomas in Laboratory Zebrafish (Danio rerio). Veterinary Pathology. 52(2):388-92
- Govindan, J., and Iovine, M.K. (2014) Hapln1a is required for connexin43-dependent growth and patterning in the regenerating fin skeleton. PLoS One. 9(2):e88574
- Perathoner, S., Daane, J.M., Henrion, U., Seebohm, G., Higdon, C.W., Johnson, S.L., Nüsslein-Volhard, C., and Harris, M.P. (2014) Bioelectric signaling regulates size in zebrafish fins. PLoS Genetics. 10(1):e1004080
- Ton, Q.V., and Iovine, M.K. (2013) Identification of an evx1-Dependent Joint-Formation Pathway during FIN Regeneration. PLoS One. 8(11):e81240
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