Genomic Feature
waw305
- ID
- ZDB-ALT-241009-2
- Name
- waw305
- Synonyms
-
- kcng4b-C2 (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Laboratory of Neurodegeneration (Kuznicki Laboratory)
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 7: 56655730 - 56655737 (GRCz11) (1) Details
- Nucleotide change
- TTCAGCCA/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 8 bp deleted in Exon 2 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
ATTGGGCCTTCAGACGCTTGGTCTTACAATGCAGAGGAGTATGCGAGAGTTTGGACTCCTGCTACTTTTCCTCTGCGTTGCTGTGGCTTTGTTCTCTCCTCTTGTCCACTTGGCAGAGAAGGAATTCAGCAAGGGCAAAGCCACTGGTCCCAATAGCTTCAGCAGCATCCCTGCGTCCTATTGGTGGGCAATCATATCCATGACCACGGTCGGCTATGGTGACATGGTGCCATACAGTATACCTGGCCAGGTTGTGGCCTTTAGCAGCATATTGAGTGGTATTCTCATTATGGCCTTTCCAGCAACATCCATCTTCCATGTGTTTTCTCGTTCATATCACGAACTGAAGCGGGAACAAGAAATGATTTATAAAGAAGAGCGAGTGGCCATCCTGGATGCCACTGCTAAAGAGGATGCCCAGAGACTGTTGAAGAGAGACTCCTTTTCTTGGGCCATTGCTAACAGAAATAGCCTGCGTAAAGACAATGGCACAGCTGCCA
TTCAGCCA/- ACCCTCACTGCTGCTGCATGTTGCAAAGATATCTGACATGTTACTTCCATTTTTTTTCTGTTGGATTTCTGTATGTTTTAATGAGTCTGCTGGAAAGAGTTTGTGTAATAAATATCTTAATCATTGAAATTAAGTTTTCAAAGATTTGACCTACCTGTTATTACATCCTCCATAGGCAGCAATAGTTCCAATATGTTCAAGAAGAGGAACCAAAGATATTGCCTAAGCATTTTATGTGACTTCAGTGGTTCAACTGTAATCACATGAAGTTCCATGAACAGTTTTGTGTGTCAAAACCTGTAAATATGACTGTGCTCACCTACAGTTAGATCCCTAAATATTTGGACGTTGACACAATTCTAACATTTTTGGCTCTATACACCAACACAATGGATTTAAAATTAAACGAACAAGACGTGCTTTAACTGCATATTGTCAGCTTTAATTTGAGTATTTACATCCAAATCAGGTGAACGCTGTAGGAATTGCAACACTTTGCA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| kcng4bwaw305/waw305 (AB) | Homozygous | ♀+/- ♂+/- | 2 figures  from Jędrychowska et al., 2024 | Fig. 8 from Jędrychowska et al., 2024 | |
| kcng4bwaw305/waw305; s356tTg (AB) | Complex | Fig. S7 from Jędrychowska et al., 2024 | Fig. S8 from Jędrychowska et al., 2024 |
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Supplemental Information
- Genotyping protocol
- None
- Jędrychowska, J., Vardanyan, V., Wieczor, M., Marciniak, A., Czub, J., Amini, R., Jain, R., Shen, H., Choi, H., Kuznicki, J., Korzh, V. (2024) Mutant analysis of Kcng4b reveals how the different functional states of the voltage-gated potassium channel regulate ear development. Developmental Biology. 513:50-62
- Gasanov, E.V., Jędrychowska, J., Pastor, M., Wiweger, M., Methner, A., Korzh, V.P. (2021) An improved method for precise genome editing in zebrafish using CRISPR-Cas9 technique. Molecular biology reports. 48(2):1951-1957
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