Genomic Feature
kbc3
Notes
No data available
Variants
- Variant Type
- Insertion
- Variant Location
- Chr 18: 6537724 - 6537725 (GRCz11) (1) Details
- Nucleotide change
- -/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 1 bp inserted in Exon 2 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
ATTTTTAGTATTACAATTCTTTTGGTTTGCAATGTTAATTAAACAAAGTTTTGTGCCGCTTCTGTTTAATATACAAGTGACACATGTAACTTATGTGATTAAAATCAGTAGCAATCAAAGCATGTAATCTCTGGAAACCTCAGGTTGGTGTTATCAGATACAAATACAGGAATTACTTGTTTGGGATAATTAAACGCTTTCGGTGCAACTCATTCAAGAAGAATTCACCTAAATAACTTAATAATTTTATTTATTGTGTGATTATTGTGTGGAATATGGCTCTGTGTATGCTTAAACTATTCGATTATTACAAACATATAAGAGTTATTTGTGTATAAAGTCATTAACCTAAGCATTAGGCGTGAACATCTTTCTGCCCTGCGGTCTTTGAAGATTGACAGGTCACAGGTGTAGTGCAGTGTGCCCAACAGATTGAAGATGAATCTCTTTCTCTCTTCCACAGTTGGTCAAGAAGGAGGGTACTGGCACCGAGTTGCCTAT
-/T GATTGGTGATAAAGTATTTGTGCACTATGTCGGAACACTGCTTGATGGCTCACAGTTCGACTCCAGCCGTGATCGAGGGGAAAAGTTCTCCTTTGAGCTGGGCAAAGGTGAGTAAGGGTGAAGTGCGCTAAATGGTAGTTCGCCCTCGCTGACTCTTAAACAGAGTCTAGGTGAATTAGATGAATTGAATCCATCTTTATTTCTGTAGCGCTTTTACAATGTAGGCTGAGTCAAAGCAGCTTAACATAGAAGTTGTAGTAGATTGAAACTGTGTCAGTCCAGTTTTCAGAGTTGAAGTTCAGTTCGACTAAAATCAGCATACTCCACGTCTAAATTCGATTTCTGTTTGGATCGATTATGACCTTAATTAGATTAAATGAATCAAATCGCTGTTTACATGGTAGACTCTTAATCAGAGTATTGTCTTAATCGTATTAATAAGATTATTGGTGTCCATGTAAACGTACTTGATGATAATCTTGACTAACTAACCTGTCTGTC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| fkbp4kbc3/kbc3 (AB) | Homozygous | ♀+/- ♂+/- | |||
| fkbp4kbc3/+ (AB) | Heterozygous | ♀+/- ♂+/- | |||
| fkbp4kbc3/kbc3; cu10Tg; zf349Tg (AB) | Complex | Fig. 4 from Lesport et al., 2024 | Fig. 4 from Lesport et al., 2024 | ||
| fkbp4kbc3/kbc3; kbc4Tg (AB) | Complex | Fig. 3 from Lesport et al., 2024 | |||
| fkbp4kbc3/+; cu10Tg; zf349Tg (AB) | Complex | Fig. 4 from Lesport et al., 2024 | Fig. 4 from Lesport et al., 2024 | ||
| fkbp4kbc3/+; kbc4Tg (AB) | Complex | Fig. 3 from Lesport et al., 2024 |
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Supplemental Information
- Genotyping protocol
- None
- Lesport, E., Commeau, L., Genet, M., Baulieu, E.E., Tawk, M., Giustiniani, J. (2024) A decrease in Fkbp52 alters autophagosome maturation and A152T-tau clearance in vivo. Frontiers in Cellular Neuroscience. 18:14252221425222
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
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