Genomic Feature
idb1
- ID
- ZDB-ALT-231002-1
- Name
- idb1
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Translational research group in new therapeutic and diagnostic strategies in liver diseases
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 7: 71328345 - 71328348 (GRCz11) (1) Details
- Nucleotide change
- AGAC/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 4 bp deleted in Exon 2 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
GTGTATATGAGAGGGAGAGACCTTTGCGCACTTACTGTAATATGTCTGAGAAAATCTAAATAATCAGCTCAGCTCTCAGAACATAGTAACCATAGTAACCTAGTAAGTCTATTCATGGACACACACACACACACACACACACACACACTATAATCAGCCGTTTTACTCCATAAAATGCTATAAAAAAAGCCCAAAACTAGTTTGCACAGGCCTATCTAAAGTGTTAATGCTGTCAACTGATGACCAACAGTAAAAATTACAAATTTTATCTCATGATTGTGGAACTAAACAAATAAAAAGCATAAATAAATGCAATAAAGCAAAGATAAAAGTGAAATAAACAGCGTTTATGGTTATGTAAATGTAAAAATGACACTGCAAAGGTATATGGAAAATTCTATGCAGTCTAACCTGTGTGGTCTTTCCAGAGCCGGTCTCTCCTACGAGCACAAAGCTCTGATGGCGGTTCAGGATGTCATTAAAGCGCTCTTTATACTCCC
AGAC/- GGGCAACTGCAGCCTCTTCTTGAGGATCTCGTAGTAGCGTGGCGTGTGAGGCAGGTTGGTGAAGGGGTTGATCTGCTGATGCATGCTGGCCTGCTTCAGAGGAAGGATTCCGCTTCCAGACACGCTGGAGCTGAGCGCCGCACTCGACGACTTGCTGTCTCTCTCTCGGTCGCGATCGCGGTCTCGGTCTCTGTCACGATCGCGCTCACGGTCCCGGTCACGATCTCGATCCTTTGATCGCTCATCCCGATCTCTGTCACGGTCCTTCCTGATGGGGAAAAAATAATGCATCCCTTAAGCTTAATCATCAAATGCATTTGGTTTGATAATTTAAGTTTCCTCATGAGCACACAAAATCTGAGCTCACAGAAATCTGCTGCTTTTTTTTAGCCAATCATTGAGTCTATTTATTTACTTAATTAAATGTGTAAATATCTCTTTATCACGTTTTTATATTAAATTCAGCAATATTTATTAACTAATATGCAAATGTCTGTATG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| dhx15idb1/idb1; la116Tg; zf3396Tg | Complex | 2 figures  from 2 publications | 2 figures from 2 publications |
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Supplemental Information
- Genotyping protocol
- None
- Portolés, I., Ribera, J., Fernandez-Galán, E., Lecue, E., Casals, G., Melgar-Lesmes, P., Fernández-Varo, G., Boix, L., Sanduzzi, M., Aishwarya, V., Reig, M., Jiménez, W., Morales-Ruiz, M. (2024) Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice. International Journal of Molecular Sciences. 25(7):
- Ribera, J., Portolés, I., Córdoba-Jover, B., Rodríguez-Vita, J., Casals, G., González-de la Presa, B., Graupera, M., Solsona-Vilarrasa, E., Garcia-Ruiz, C., Fernández-Checa, J.C., Soria, G., Tudela, R., Esteve-Codina, A., Espadas, G., Sabidó, E., Jiménez, W., C Sessa, W., Morales-Ruiz, M. (2021) The loss of DHX15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice. Communications biology. 4:1192
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