Genomic Feature
y689
- ID
- ZDB-ALT-220929-6
- Name
- y689
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with TALEN
- Lab of Origin
- Bergeron Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 5: 67910651 - 67910661 (GRCz11) (1) Details
- Nucleotide change
- TGGATATGCAG/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 11 bp deleted in Exon 1 (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
GCATTCAAGATTCCACAGGTGTGGCGTACAGAGTCTTTTGAGGTGATGGTCATGTTCACGGGCTGACGGACAGGTCTGCGTCCTCTTTCTCTGATGACGGGGGAGACATTGGGAGGTCATCCTCTTCCTCGGAGCACCGGGCGGAGGACAGGGAGGATGAGCACTTGCAGTTGTGCGCGCCCGTTCTGTGGGAGCCGCTTTTGCCTTCTTTTTTGTGCTTTACGCGGCGGTTCTGGAACCAAATCTTGACTTGCTTCTCGGATAGATTGAGGTAAGTTGCGATCTCTATGCGCCGAAGTCTCGACAGGTACATGTTGGAGGTGAACTCCCTTTCCAACTCCAAGAGTTGCGTGCTGGTGAACGCAGTGCGCATGCGTTTGCTGCTCTGAAGTTGACTGCTGCTATTTTCTGTTGAACAATAAACAAAAAGTTAAGTTGCTGATATACATAAAAAGTTTAATTGCAAAACTTTTTCAATGCACAAATGACACACTTACCTA
TGGATATGCAG/- TGGAACTGTCGTGGATCTGGAACCGGATAAGCGGCTTGATATAAGCCAGAGCCGCTGTTGAGGTTTACGCCGCTGGATGTGGAGTGCTGTCTGGAGAGCGCGGAGTGGCAATACTGGGTGCCGAACGCTGGAAATGAAGCCTTGATGAGGGGCAGCGCTGGGGGAGATGGGTGAAGCTGAGAAGTGACGCACAGCGGGCAAAAGCACAGCAGACCCGCTTTTCGAGAGTGGCAGGAGCCGGCGGAGAGGCTGTGGAGAGGATGAGAAGGATGCACCGCGTACGGAAATAACGGAGGGCTGTTCTCTGTGCCCTTTTCGCTGTTCTCCCTCAAAATCAAGGAATCCACAAGAAAGGATCTTGGCATCTTGACAGCGCCGTGTGTCTTCACCTGATGTCTGTTAGAAAGTTTCAGTCTCGCTCGTGTACCAAATGCTGGATGGCAGAATGGTGCTGAGGAGAAAGTGTCCCTGCTTAAATAGTTGGAGAGCCAGTGCGCCCA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| gsx1y689/y689 | Homozygous | ♀+/- ♂+/- | Fig. 7  from Coltogirone et al., 2022 | 3 figures from Coltogirone et al., 2022 | |
| gsx1y689/+ | Heterozygous | ♀+/- ♂+/- | Fig. 7 from Coltogirone et al., 2022 | ||
| gsx1y689/+ (AB) | Heterozygous | ♀+/- ♂+/- | |||
| gsx1y689/+; gsx1y690/+ | Complex | Fig. 9 from Coltogirone et al., 2022 | |||
| gsx1y689/y689; gsx2y691/y691 | Complex | 2 figures from Coltogirone et al., 2022 |
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Supplemental Information
- Genotyping protocol
- None
- Schmidt, A.R., Placer, H.J., Muhammad, I.M., Shephard, R., Patrick, R.L., Saurborn, T., Horstick, E.J., Bergeron, S.A. (2024) Transcriptional control of visual neural circuit development by GS homeobox 1. PLoS Genetics. 20:e1011139e1011139
- Coltogirone, R.A., Sherfinski, E.I., Dobler, Z.A., Peterson, S.N., Andlinger, A.R., Fadel, L.C., Patrick, R.L., Bergeron, S.A. (2022) Gsx2, but not Gsx1, is necessary for early forebrain patterning and long-term survival in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(3):377-399
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