Genomic Feature
zju1
- ID
- ZDB-ALT-220823-1
- Name
- zju1
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one delins (1)
- Protocol
- embryos treated with
- Lab of Origin
- Jinrong Peng Lab
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 5: 1869438 (GRCz11) (1) Details
- Nucleotide change
- A/CTGGATTGTCCTGGATT
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 17 bp inserted / 1 bp deleted (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
AATAAAAGTTTGTTTTTACATATAACTATTATAATAAATATACATTAAATTTAATACACATACATTTATCTAAATATGAACACTTTCTCAATTATATGCATGGGTGTATTTAAATATACGTAATAACAACATCATCATACACACAGCGCACACACTTACAATGTCAAAACTAACTTTTATTTTGGTGCGATTAATCGAGATAGATTTTTGCCCAGAAAATTAACCAGTGAAGTATAAACACAGAAAATTTAAATGAACATTATTACTAATATTAGAAATAAATAAACTGAACTGCAGACTTATGGAGTGCAGAAATAAACATTTAATTAAATATGTAAAACATTTATAAAACATTAACATCTTGGAATAACTCGACGGTGTGTATTCTAGATTTCTGGTGTTGTCCTGACAGATATTTAAAGTACAGATGAGTGTAATGGATTGTTGACAGAGAGAGAGTGTGTGTTTGTGTGTGCGTGTGTGTTTGTGACGCACCTCTC
A/CTGGATTGTCCTGGATT GTCCTGGATTGTCGTCTTTGGATCTGATGTTTCGTATCTTCACTGGTTTTCCACTTAATGTGGACAGCACGAGTCTCTGTCTAAAACCGCTACAACCTTCAAACTCCATGATTAAAAGAAAAATCCACTCACTCGCATTTACACACACACACACACACTCTCTCACACACGTGTTTCTACTGCGATACAGACGCCACACCGACGCGTGACGGCAGAGCGCGAGGGACAAAACGCAAAACGCGAAGCAGAAAAGAAGACGCTACATCATATTAGCCACAAGAGGTCAACAAACTCAATATAAACATTCCAAATTGTTCAATTAAAGAGCCAGATCAGCCAAAAATAAACATTAAAAACCTGATAAAAATCTGTTCTACACAAAATAAAATATTAATGAAAACATAATGTCAATTTCTAGCAAATAGTATTATGTTTTTAACCATACTACAGTAAATTACTTGGATTTATCAGTATTAATTCTACACGCTATAAAACATACA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| rcl1zju1/zju1 (AB) | Homozygous | ♀+/- ♂+/- | 2 figures  from Zhu et al., 2021 | Fig. 2 from Zhu et al., 2021 |
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Supplemental Information
- Genotyping protocol
- None
- Wang, Y., Zhao, Z., Yu, H., Shi, H., Tao, B., He, Y., Chen, J., Peng, J., Gan, M., Lo, L.J. (2023) Stability and function of RCL1 are dependent on interaction with BMS1. Journal of molecular cell biology. 15(7):
- Zhu, Q., Tao, B., Chen, H., Shi, H., Huang, L., Chen, J., Hu, M., Lo, L.J., Peng, J. (2021) Rcl1 depletion impairs 18S pre-rRNA processing at the A1-site and up-regulates a cohort of ribosome biogenesis genes in zebrafish. Nucleic acids research. 49(10):5743-5759
- Zhu, Y., Wang, Y., Tao, B., Han, J., Chen, H., Zhu, Q., Huang, L., He, Y., Hong, J., Li, Y., Chen, J., Huang, J., Lo, L.J., Peng, J. (2021) Nucleolar GTPase Bms1 displaces Ttf1 from RFB-sites to balance progression of rDNA transcription and replication. Journal of molecular cell biology. 13(12):902-917
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