Genomic Feature
nii2
- ID
- ZDB-ALT-220329-1
- Name
- nii2
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one insertion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Matsui Lab
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Insertion
- Variant Location
- Chr 16: 14217058 - 14217059 (GRCz11) (1) Details
- Nucleotide change
- -/ATCA
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 4 bp inserted (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
GTGACCGTTCCGCATTTTCACCAGGAAATCAGTCGCATGGCGCGTGATTGACTGTTTACATTCTCGAAACACATCAGACTGGACTTTTAAACATCTTTTAGAGAACCATAATGACATTGCCATTTTCGTTTTTAGGCCTCGGATAAACTTTAAATCGTCACAAATCTTAAAAGATTAAGTATTTGAATGGGCGTTCATTAACGTACACGGGAGTCTCATCGGCAGGATGAGAGAAACGGCTCTTTTTATTCTGCTCGCCGGAATAATCACCACAGCAAGAGGTGTGTAACAATAATCAGACGGATTATATAAGATTTACCTTTCTGTCCAAGTGTTTGTTTTGATCTTTCTGCTTTTTTGTTTCACTTTGGCTCAGCTGACAGTAAAGACGGTTGTCTAGCACTGAATTTCGGTCATGGCTCGGTTGTGTGTGTGTGCAATGCGACATACTGCGACTCTCTCGGCCGGACTGTGCTGCCAGATGCTGGTCAGTTCTTATCA
-/ATCA TATGTCAGCAATAAAGCTGGCAGCAGACTGATGGAGAGTCAAGGACAGTTCCAGAAGAACAGCACAGGTGCAGGTGAGTGCTCTTAAGAGACCATGGCCATGTCCCAGTACTCAAACTAACGGTCTGCTCACTAGTGTTCTGTTTACTGTAACACTTATGTGTTAATCTGATGTAAATCCTGTATCAGTTTGTGTTCTAAAATGAGAATTTTCCTCAGCCTTAAGTTTATTTTAATTTATTTCACTTTAAAAGCAATGGAAAGAACATCATTTGCCATAAAAGTAAAGTGACTAAACCTACATTTTAGCTCATTTTAGAAAAAAAATTCAAATGGATCTTATTGGATTTTGCATCTCAACGCTTCAACGCTTCATTTTGATTAAATTATGGAATACATTTTACACAGTGTAGATTCGGAAAATGTAAGAATCGTTTTAAACAAGATTTAAATGAAGATGTAATATTTTACACACGCTGGAGGCCTACATTTCTGTTCAATA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| gba1nii2/nii2 | Homozygous | Unknown | Fig. 4  from Matsui et al., 2021 | Fig. 4 from Matsui et al., 2021 |
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Supplemental Information
- Genotyping protocol
- None
- Matsui, H., Ito, S., Matsui, H., Ito, J., Gabdulkhaev, R., Hirose, M., Yamanaka, T., Koyama, A., Kato, T., Tanaka, M., Uemura, N., Matsui, N., Hirokawa, S., Yoshihama, M., Shimozawa, A., Kubo, S.I., Iwasaki, K., Hasegawa, M., Takahashi, R., Hirai, K., Kakita, A., Onodera, O. (2023) Phosphorylation of α-synuclein at T64 results in distinct oligomers and exerts toxicity in models of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 120:e2214652120e2214652120
- Matsui, H., Ito, J., Matsui, N., Uechi, T., Onodera, O., Kakita, A. (2021) Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson's disease. Nature communications. 12:3101
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